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Predicting topical drug clearance from the skin
- Source :
- Drug Delivery and Translational Research
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- For topical drug products that target sites of action in the viable epidermal and/or upper dermal compartment of the skin, the local concentration profiles have proven difficult to quantify because drug clearance from the viable cutaneous tissue is not well characterised. Without such knowledge, of course, it is difficult—if not impossible—to predict a priori whether and over what time frame a topical formulation will permit an effective concentration of drug within the skin ‘compartment’ to be achieved. Here, we test the hypothesis that valuable information about drug disposition, and specifically its clearance, in this experimentally difficult-to-access compartment (at least, in vivo) can be derived from available systemic pharmacokinetic data for drugs administered via transdermal delivery systems. A multiple regression analysis was undertaken to determine the best-fit empirical correlation relating clearance from the skin to known or easily calculable drug properties. It was possible, in this way, to demonstrate a clear relationship between drug clearance from the skin and key physical chemical properties of the drug (molecular weight, log P and topological polar surface area). It was further demonstrated that values predicted by the model correlated well with those derived from in vitro skin experiments.
- Subjects :
- Drug
Metabolic Clearance Rate
Transdermal patch
Skin Absorption
media_common.quotation_subject
Pharmaceutical Science
Drug Elimination Routes
Pharmacology
Administration, Cutaneous
030226 pharmacology & pharmacy
Polar surface area
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
Pharmacokinetics
In vivo
Dermato-pharmacokinetics
Medicine
Compartment (pharmacokinetics)
Skin
media_common
Transdermal
Topical drug
integumentary system
business.industry
Skin clearance
030220 oncology & carcinogenesis
Original Article
Drug disposition
business
Subjects
Details
- ISSN :
- 21903948 and 2190393X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Drug Delivery and Translational Research
- Accession number :
- edsair.doi.dedup.....9bb2747d9a5a56d054505e960de1d3ea
- Full Text :
- https://doi.org/10.1007/s13346-020-00864-8