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WAO-ARIA consensus on chronic cough - Part II: Phenotypes and mechanisms of abnormal cough presentation — Updates in COVID-19

Authors :
Lianglu Wang
Sami L. Bahna
Luis Caraballo
Jean Bousquet
David B. Peden
Sandra Nora González Díaz
Luciana Kase Tanno
Georges S. Juvelekian
Giorgio Walter Canonica
Ludger Klimek
Ignacio J. Ansotegui
Yoon-Seok Chang
Jose Antonio Ortego-Martell
Adnan Custovic
Moussa A. Riachy
Bryan Martin
Samar A. Idriss
Peter K. Smith
Gary W.K. Wong
René Maximiliano Gómez
Erika Jensen-Jarolim
Mona Al-Ahmad
Tanya M. Laidlaw
Jonathan A. Bernstein
Cecilio Azar
Philip W. Rouadi
Alessandro Fiocchi
Michael Levin
Eliane Abou-Jaoude
Motohiro Ebisawa
Talal M. Nsouli
Mário Morais-Almeida
Usamah Hadi
Maryam Ali Al-Nesf
Fares Zaitoun
Glenis Scadding
James L. Sublett
Manana Chikhladze
Anahí Yáñez
Peter Hellings
Beirut Eye & ENT Specialist Hospital (BESH)
Hôpital Edouard Herriot [CHU - HCL]
Hospices Civils de Lyon (HCL)
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Berlin Institute of Health (BIH)
Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR)
Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA)
Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Brigham and Women’s Hospital [Boston, MA]
Harvard Medical School [Boston] (HMS)
American University of Beirut [Beyrouth] (AUB)
Middle East Institute of Health
Clemenceau Medical Center (CMC)
Kuwait University
Investigaciones en Alergia y Enfermedades Respiratorias (InAER)
Hamad Medical Corporation [Doha, Qatar]
International Cough Institute (ICI)
Louisiana State University (LSU)
LAU Medical Center-Rizk Hospital
American University of Beirut Faculty of Medicine and Medical Center (AUB)
Department of Microbiology, Immunology and Transplantation [Leuven]
Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)
University Hospitals Leuven [Leuven]
Ghent University Hospital
Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC)
University of Amsterdam [Amsterdam] (UvA)
The Royal National Throat, Nose and Ear Hospital [London, UK]
University College of London [London] (UCL)
Griffith University [Brisbane]
Hospital CUF Descobertas
Catholic University of Salta
Universidad Autonoma de Nuevo Leon [Mexique] (UANL)
Center for Rhinology and Allergology Wiesbaden
University Hospital Mannheim
Saint George Hospital University Medical Center [UOB LIBAN]
University of Balamand [Liban] (UOB)
Hôtel-Dieu de France (HDF)
Université Saint-Joseph de Beyrouth (USJ)
Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
University of North Carolina [Chapel Hill] (UNC)
University of North Carolina System (UNC)
The Chinese University of Hong Kong [Hong Kong]
University of Louisville
University of Cincinnati College of Medicine
Peking Union Medical College Hospital [Beijing] (PUMCH)
Institut Desbrest de santé publique (IDESP)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
World Health Organisation (WHO)
Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)
Akaki Tsereteli State University
University of Cape Town
Seoul National University Bundang Hospital (SNUBH)
The Ohio State University Wexner Medical Center.
University of Cartagena
Imperial College London
Universidad Autónoma del Estado de Hidalgo (UAEH)
Medizinische Universität Wien = Medical University of Vienna
Sagamihara National Hospital [Kanagawa, Japan]
Bambino Gesù Children’s Hospital [Rome, Italy]
Hospital Quirónsalud Bizkaia [Bilbao]
Salvy-Córdoba, Nathalie
Source :
World Allergy Organization Journal, Vol 14, Iss 12, Pp 100618-(2021), The World Allergy Organization Journal, World Allergy Organization Journal, World Allergy Organization Journal, 2021, 14 (12), pp.100618. ⟨10.1016/j.waojou.2021.100618⟩
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

BACKGROUND: Chronic cough can be triggered by respiratory and non-respiratory tract illnesses originating mainly from the upper and lower airways, and the GI tract (ie, reflux). Recent findings suggest it can also be a prominent feature in obstructive sleep apnea (OSA), laryngeal hyperresponsiveness, and COVID-19. The classification of chronic cough is constantly updated but lacks clear definition. Epidemiological data on the prevalence of chronic cough are informative but highly variable. The underlying mechanism of chronic cough is a neurogenic inflammation of the cough reflex which becomes hypersensitive, thus the term hypersensitive cough reflex (HCR). A current challenge is to decipher how various infectious and inflammatory airway diseases and esophageal reflux, among others, modulate HCR. OBJECTIVES: The World Allergy Organization/Allergic Rhinitis and its Impact on Asthma (WAO/ARIA) Joint Committee on Chronic Cough reviewed the current literature on classification, epidemiology, presenting features, and mechanistic pathways of chronic cough in airway- and reflux-related cough phenotypes, OSA, and COVID-19. The interplay of cough reflex sensitivity with other pathogenic mechanisms inherent to airway and reflux-related inflammatory conditions was also analyzed. OUTCOMES: Currently, it is difficult to clearly ascertain true prevalence rates in epidemiological studies of chronic cough phenotypes. This is likely due to lack of standardized objective measures needed for cough classification and frequent coexistence of multi-organ cough origins. Notwithstanding, we emphasize the important role of HCR as a mechanistic trigger in airway- and reflux-related cough phenotypes. Other concomitant mechanisms can also modulate HCR, including type2/Th1/Th2 inflammation, presence or absence of deep inspiration-bronchoprotective reflex (lower airways), tissue remodeling, and likely cough plasticity, among others. ispartof: WORLD ALLERGY ORGANIZATION JOURNAL vol:14 issue:12 ispartof: location:United States status: published

Details

ISSN :
19394551
Volume :
14
Database :
OpenAIRE
Journal :
World Allergy Organization Journal
Accession number :
edsair.doi.dedup.....9bc305d2c05b120ee5ca8a5f860e10ba