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Preparation and investigation of high solid content PTX-loaded nanoparticles dispersion via nanoprecipitation method
- Source :
- Journal of Biomaterials Science, Polymer Edition. 25:1144-1158
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- The improvement of the solid content of the hydrophobic drugs (such as paclitaxel (PTX), etc.) loaded nanoparticles (NPs) dispersion is important for enhancing drug-loaded efficiency and reducing the cost in production and application. A diblock copolymer methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (mPECT) is synthesized via the ring-opening polymerization of ε-caprolactone and 1,4,8-trioxa[4.6]spiro-9-undecanone (TOSUO) with methoxy poly(ethyleneglycol) (mPEG) as the initiator. The chemical structures and thermal properties of mPECT are characterized by (1)HNMR, Fourier transform infrared (FT-IR), gel permeation chromatography, differential scanning calorimetry, etc. PEG45.45-b-P(C28.33-co-T5.38) (mPECT-2) is able to self-assemble into stable NPs in water via nanoprecipitation method at a high solid content (≤25 wt%) and their freeze-dried powders can well re-disperse in water. The paclitaxel (PTX) is chosen as a hydrophobic drug model and successfully encapsulate into the mPECT-2 NPs via the same method at a high solid content. The encapsulation efficiency, cytotoxicity and in vitro release of PTX-loaded NPs are investigated. The results suggest that the behavior of the drug-loaded mPECT-2 NPs prepared at a solid content of 25 wt% is similar to that of NPs prepared at a solid content of 1 wt%, which indicate that increasing solid content of polymer has no negative effect on the properties of NPs dispersion in application. In summary, the freeze-dried NPs prepared from the high solid content dispersion (≤25 wt%) has a good redispersibility and exhibits great potential in cost control of preparing NPs dispersion used as drug delivery system.
- Subjects :
- Materials science
Paclitaxel
Cell Survival
Polyesters
Biomedical Engineering
Biophysics
Nanoparticle
Bioengineering
Nanocapsules
Polyethylene Glycols
Biomaterials
Gel permeation chromatography
chemistry.chemical_compound
Differential scanning calorimetry
Microscopy, Electron, Transmission
Cell Line, Tumor
Spectroscopy, Fourier Transform Infrared
Copolymer
Humans
Organic chemistry
Particle Size
chemistry.chemical_classification
Calorimetry, Differential Scanning
technology, industry, and agriculture
Polymer
Antineoplastic Agents, Phytogenic
Freeze Drying
Nanomedicine
chemistry
Chemical engineering
Delayed-Action Preparations
Drug delivery
Hydrophobic and Hydrophilic Interactions
Ethylene glycol
Subjects
Details
- ISSN :
- 15685624 and 09205063
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Biomaterials Science, Polymer Edition
- Accession number :
- edsair.doi.dedup.....9bd614d4bac3b91afc32244ba3784906