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The fatty acid-based erythrocyte membrane lipidome in dogs with chronic enteropathy
- Source :
- Animals, Vol 11, Iss 2604, p 2604 (2021), Animals, Volume 11, Issue 9, Animals : an Open Access Journal from MDPI
- Publication Year :
- 2021
-
Abstract
- Canine chronic enteropathies (CEs) are inflammatory processes resulting from complex interplay between the mucosal immune system, intestinal microbiome, and dietary components in susceptible dogs. Fatty acids (FAs) play important roles in the regulation of physiologic and metabolic pathways and their role in inflammation seems to be dual, as they exhibit pro–inflammatory and anti–inflammatory functions. Analysis of red blood cell (RBC) membrane fatty acid profile represents a tool for assessing the quantity and quality of structural and functional molecular components. This study was aimed at comparing the FA membrane profile, determined by Gas Chromatography and relevant lipid parameter of 48 CE dogs compared with 68 healthy dogs. In CE patients, the levels of stearic (p &lt<br />0.0001), dihomo–gamma–linolenic, eicosapentaenoic (p = 0.02), and docosahexaenoic (p = 0.02) acids were significantly higher, and those of palmitic (p &lt<br />0.0001) and linoleic (p = 0.0006) acids were significantly lower. Non-responder dogs presented higher percentages of vaccenic acid (p = 0.007), compared to those of dogs that responded to diagnostic trials. These results suggest that lipidomic status may reflect the “gut health”, and the non–invasive analysis of RBC membrane might have the potential to become a candidate biomarker in the evaluation of dogs affected by CE.
- Subjects :
- medicine.medical_specialty
040301 veterinary sciences
Veterinary medicine
Vaccenic acid
Inflammation
membrane fatty acids
Article
Red blood cell membrane lipidome
Canine chronic enteropathy
Protein-losing enteropathy
0403 veterinary science
Lipidomic profile
Membrane fatty acids
Non-responsive enteropathy
03 medical and health sciences
chemistry.chemical_compound
Immune system
Internal medicine
SF600-1100
medicine
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
General Veterinary
Membrane fatty acid
Fatty acid
04 agricultural and veterinary sciences
Lipidome
Red blood cell
Metabolic pathway
medicine.anatomical_structure
Endocrinology
chemistry
QL1-991
Biomarker (medicine)
Animal Science and Zoology
medicine.symptom
Zoology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Animals, Vol 11, Iss 2604, p 2604 (2021), Animals, Volume 11, Issue 9, Animals : an Open Access Journal from MDPI
- Accession number :
- edsair.doi.dedup.....9be3943abcce5b2ecda98ff4abaa23b7