Back to Search
Start Over
Fenugreek Improves Diet-induced Metabolic Disorders in Rats
- Source :
- Hormone and Metabolic Research. 43:950-955
- Publication Year :
- 2011
- Publisher :
- Georg Thieme Verlag KG, 2011.
-
Abstract
- Trigonella foenum-graecum L. (fenugreek) has been described earlier and its use in ancient medicinal practice is well known. The hypoglycemic effects of fenugreek have been studied in many animal models and diabetic patients. The purpose of this study was to examine the preventive efficiency of dietary fenugreek on diet-induced metabolic diseases in rats. The diets used in this study were a standard diet, a high-fat high-sucrose (HFS) diet, and a HFS diet containing 0.5 g/kg b. w./day fenugreek based on the modified version of the AIN-93G purified diet, for 12 weeks, respectively. The rats fed the HFS diet containing fenugreek showed significantly lower fasting insulin levels and HOMA-IR than the rats fed the HFS diet. Therefore, fenugreek improved insulin sensitivity in rats. The triglyceride and total cholesterol levels in the plasma were significantly lower in the fenugreek-administered group. Moreover, distinct reductions of triglyceride, total cholesterol, free fatty acid, and phospholipid levels in the liver were found in the rats fed the HFS diet containing fenugreek. These results suggest that fenugreek enhanced insulin sensitivity at least partly by improving lipid metabolism disorders in the plasma and the liver in the rats induced by the HFS diet.
- Subjects :
- Male
medicine.medical_specialty
Lipid Metabolism Disorder
Trigonella
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Phospholipid
Diet, High-Fat
Biochemistry
Rats, Sprague-Dawley
chemistry.chemical_compound
Endocrinology
Insulin resistance
Metabolic Diseases
Internal medicine
Dietary Carbohydrates
medicine
Animals
Humans
Triglycerides
chemistry.chemical_classification
integumentary system
biology
Triglyceride
Plant Extracts
Biochemistry (medical)
Fatty acid
Lipid metabolism
General Medicine
medicine.disease
biology.organism_classification
Dietary Fats
Rats
Cholesterol
Liver
chemistry
Hypoglycemic Effects
Insulin Resistance
Subjects
Details
- ISSN :
- 14394286 and 00185043
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Hormone and Metabolic Research
- Accession number :
- edsair.doi.dedup.....9be65755456b194615ace20a3f538e9c