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Effects of Mixed of a Ketogenic Diet in Overweight and Obese Women with Polycystic Ovary Syndrome
- Source :
- International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health; Volume 18; Issue 23; Pages: 12490, International Journal of Environmental Research and Public Health, Vol 18, Iss 12490, p 12490 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Polycystic ovary syndrome (PCOS) is a commonly occurring endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Often comorbid with insulin resistance, dyslipidemia, and obesity, it also carries significant risk for the development of cardiovascular and metabolic sequelae, including diabetes and metabolic syndrome. The relationship between central obesity and the development of insulin resistance is widely verified. Adipose tissue excess and the coexistent dysregulation of adipocyte functions directly contribute to the pathogenesis of the metabolic complications observed in women with PCOS. In the light of these evidence, the most therapeutic option prescribed to obese women with PCOS, regardless of the phenotype e from the severity of clinical expression, is lifestyle correction by diet and physical activity. The aim of this study is to evaluate the beneficial effects of ketogenic diet in 17 obese women with PCOS. Our results showed that the ketogenic diet inducing therapeutic ketosis, improves the anthropometric and many biochemical parameters such as LH, FSH, SHBG, insulin sensitivity and HOMA index. In addition, it induces a reduction in androgenic production, whereas the contextual reduction of fat mass reduced the acyclic production of estrogens deriving from the aromatization in the adipose tissue of the androgenic excess, with an improvement of the LH/FSH ratio. This is the first study on the effects of the ketogenic diet on PCOS, however, further studies are needed to elucidate the mechanism underlying ketogenic diet effects.
- Subjects :
- medicine.medical_specialty
obesity
ketogenic diet (KD)
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Article
Body Mass Index
Anovulation
Insulin resistance
Internal medicine
insulin resistance
adipose tissue (AT)
medicine
Humans
Insulin
hormone production
polycystic ovary syndrome (PCOS)
women
business.industry
Polycystic ovary syndrome (PCOS)
Public Health, Environmental and Occupational Health
Overweight
medicine.disease
Polycystic ovary
Endocrinology
Medicine
Female
Ketosis
Metabolic syndrome
business
Diet, Ketogenic
Dyslipidemia
Ketogenic diet
Polycystic Ovary Syndrome
Subjects
Details
- Language :
- English
- ISSN :
- 16604601 and 16617827
- Volume :
- 18
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....9beca02fa5a24af56f5743998f17178d