Back to Search
Start Over
Effect of Rapeseed and Dietary Oils on the Mean Survival Time of Stroke-Prone Spontaneously Hypertensive Rats
- Source :
- Biological and Pharmaceutical Bulletin. 19:554-557
- Publication Year :
- 1996
- Publisher :
- Pharmaceutical Society of Japan, 1996.
-
Abstract
- Low-fat conventional diets supplemented with 5 or 10% vegetable oils were fed to stroke-prone spontaneously hypertensive rats (SHR-SP) from weaning and the mean survival times were determined. A 1% aqueous sodium chloride solution was used as drinking water throughout the experiments. In four separate experiments, the rapeseed oil group showed a significantly shorter mean survival time. The relative mean survival times were 50-59% (rapeseed oil group), 78-100% (soybean oil group) and 86% (microbial oil group) as compared with the group fed perilla oil (100%). The group which received 4-fold diluted rapeseed oil exhibited a significantly shorter survival time as compared with the group receiving soybean oil. Although the feeding experiments were performed under very simple and restricted conditions, these results suggest that the rapeseed oil prepared for human use contains a factor (s) which is toxic to SHR-SP rats.
- Subjects :
- medicine.medical_specialty
food.ingredient
Rapeseed
Sodium
Pharmaceutical Science
chemistry.chemical_element
Soybean oil
Fatty Acids, Monounsaturated
Animal science
food
Dietary Fats, Unsaturated
Rats, Inbred SHR
Mean Survival Time
Animals
Plant Oils
Medicine
Weaning
Survival rate
Stroke
Pharmacology
business.industry
Fatty Acids
Brain
General Medicine
medicine.disease
Dietary Fats
Perilla oil
Rats
Surgery
Survival Rate
Cerebrovascular Disorders
Liver
chemistry
Hypertension
Rapeseed Oil
business
Subjects
Details
- ISSN :
- 13475215 and 09186158
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Biological and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....9c284413c587ea821726cb0017b3264f