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The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)
- Publication Year :
- 2021
-
Abstract
- Background Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. Methods The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014. Results Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults. Conclusions To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.
- Subjects :
- Adult
Pediatrics
medicine.medical_specialty
Cancer Research
epidemiological study
population-based cancer registries
Databases, Factual
Population
health care disparities
histology
International Classification of Diseases
primary brain tumor
Socio-culturale
Cancer registration
610 Medicine & health
Astrocytoma
03 medical and health sciences
Global population
0302 clinical medicine
epidemiological study, health care disparities, histology, International Classification of Diseases, population-based cancer registries, primary brain tumor
medicine
Humans
1306 Cancer Research
Registries
education
Child
Medulloblastoma
education.field_of_study
business.industry
Brain Neoplasms
Cancer
Histology
10060 Epidemiology, Biostatistics and Prevention Institute (EBPI)
medicine.disease
Europe
2728 Neurology (clinical)
Oncology
030220 oncology & carcinogenesis
Population study
2730 Oncology
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15228517
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9c3112d0dcb877510a5daa4253fee384