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Endurance training on rodent brain antioxidant capacity: A meta-analysis
- Source :
- Neuroscience Research. 145:1-9
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The influence of physical exercise on brain antioxidant defense mechanisms has been studied. Nevertheless, the effect of training volume on the brain`s redox balance remains unclear. In this meta-analysis, we compared the effect of training volume on antioxidant enzymatic resource and lipid peroxidation on various brain regions. The activities of the enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and the levels of thiobarbituric acid reactive substances (TBARS) were also evaluated. The effects of training periods (weeks) and exercise duration were compared. Meta-analysis revealed that protocols over 8 weeks were associated with an increase in SOD (p = 0.0008) and CAT activities (p = 0.0001). Exercise durations for 30 and 60 min were associated with higher CAT activity (p = 0.04). Joint analysis revealed that moderate physical exercise over 4 and 8 weeks promoted a healthy enzymatic balance. However, high volumes of exercise over 8 weeks were associated with the increased antioxidant enzymatic activity, indicating higher reactive oxygen species (ROS) levels. The data also indicated that there is still limited research and inaccurate information, on the safety conditions of training periods that simulate tests of ultra resistance in humans.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Rodentia
Physical exercise
medicine.disease_cause
Superoxide dismutase
Lipid peroxidation
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endurance training
Internal medicine
TBARS
medicine
Animals
chemistry.chemical_classification
Glutathione Peroxidase
biology
Superoxide Dismutase
business.industry
General Neuroscience
Glutathione peroxidase
Brain
General Medicine
Catalase
Rats
Endurance Training
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
biology.protein
Reactive Oxygen Species
business
Oxidation-Reduction
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 01680102
- Volume :
- 145
- Database :
- OpenAIRE
- Journal :
- Neuroscience Research
- Accession number :
- edsair.doi.dedup.....9c38d11f9b8d2de205ae029e03e27a24