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A multiāinstitutional validation study of prognostic nomograms for retroperitoneal sarcoma
- Source :
- Journal of Surgical Oncology. 124:829-837
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background and objectives Prognostic nomograms for patients undergoing resection of retroperitoneal sarcoma (RPS) include the Sarculator and Memorial Sloan Kettering (MSK) sarcoma nomograms. We sought to validate the Sarculator and MSK nomograms within a large, modern multi-institutional cohort of patients with primary RPS undergoing resection. Methods Patients who underwent resection of primary RPS between 2000 and 2017 across nine high-volume US institutions were identified. Predicted 7-year disease-free (DFS) and overall survival (OS) and 4-, 8-, and 12-year disease-specific survival (DSS) were calculated from the Sarculator and MSK nomograms, respectively. Nomogram-predicted survival probabilities were stratified in quintiles and compared in calibration plots to observed survival outcomes assessed by Kaplan-Meier estimates. Discriminative ability of nomograms was quantified by Harrell's concordance index (C-index). Results Five hundred and two patients underwent resection of primary RPS. Histologies included leiomyosarcoma (30%), dedifferentiated liposarcoma (23%), and well-differentiated liposarcoma (15%). Median tumor size was 14.0 cm (interquartile range [IQR], 8.5-21.0 cm). Tumor grade distribution was: Grade 1 (27%), Grade 2 (17%), and Grade 3 (56%). Median DFS was 31.5 months; 7-year DFS was 29%. Median OS was 93.8 months; 7-year OS was 51%. C-indices for 7-year DFS, and OS by the Sarculator nomogram were 0.65 (95% confidence interval [CI]: 0.62-0.69) and 0.69 (95%CI: 0.65-0.73); plots demonstrated good calibration for predicting 7-year outcomes. The C-index for 4-, 8-, and 12-year DSS by the MSK nomogram was 0.71 (95%CI: 0.67-0.75); plots demonstrated similarly good calibration ability. Conclusions In a diverse, modern validation cohort of patients with resected primary RPS, both Sarculator and MSK nomograms demonstrated good prognostic ability, supporting their ongoing adoption into clinical practice.
- Subjects :
- Male
Leiomyosarcoma
medicine.medical_specialty
Liposarcoma
Interquartile range
medicine
Humans
Retroperitoneal sarcoma
Retroperitoneal Neoplasms
Aged
Retrospective Studies
business.industry
Sarcoma
General Medicine
Middle Aged
Nomogram
Prognosis
medicine.disease
Confidence interval
Survival Rate
Nomograms
Oncology
Surgical Procedures, Operative
Cohort
Female
Surgery
Radiology
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 10969098 and 00224790
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....9c468a521109f52584d0f35b404335ba