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Effects of endogenous molasses carbon dots on macrophages and their potential utilization as anti-inflammatory agents
- Source :
- Applied Physics A. 126
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- WOS: 000502807900008<br />The biological effect of endogenous food-borne carbon dots (CDs) is one of the controversial issues of current research areas in food biotechnology. In this study, the biocompatibility and biofunctionality of sugar beet molasses-derived fluorescent carbon dots (CDs) were investigated for the first time in mammalian macrophage and fibroblast cells. The molasses CDs were nearly spherical in shape and monodispersed with a typical amorphous structure and a particle size distribution in the range of 1.3-3.8 nm. The anionic molasses CDs could easily enter the cells and exhibited excellent biocompatibility. Importantly, CDs with high photostability not only enabled the intracellular tracking of the nanomaterials by confocal microscopy, but also could reduce the LPS-induced NO production in RAW 264.7 cells. Altogether, endogenous CDs with dual functionality, bioimaging and anti-inflammatory effect, are believed to have great potential as macrophage-mediated theranostic agents.
- Subjects :
- Biocompatibility
medicine.drug_class
chemistry.chemical_element
Endogeny
02 engineering and technology
01 natural sciences
anti-inflammatory agents
Anti-inflammatory
law.invention
Nanomaterials
Confocal microscopy
law
0103 physical sciences
medicine
General Materials Science
endogenous molasses carbon
010302 applied physics
General Chemistry
021001 nanoscience & nanotechnology
Fluorescence
macrophages
chemistry
Biophysics
0210 nano-technology
Carbon
Intracellular
Subjects
Details
- ISSN :
- 14320630 and 09478396
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Applied Physics A
- Accession number :
- edsair.doi.dedup.....9c4808c6aab0cd8142a0a382bbbe4dbe