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What Can Be Learned From Crowdsourced Population Asparagus Urinary Odor Kinetics?
- Source :
- CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 407-414 (2019), CPT: Pharmacometrics & Systems Pharmacology
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Asparagus consumption is associated with the production of malodorous urine. Interindividual variability was previously characterized by an American Society for Clinical Pharmacology and Therapeutics crowdsourced study. To further characterize urinary odor kinetics, we conducted a study with consenting participants from Takeda Pharmaceutical International Company. The participants were randomized to consume a specified number of asparagus spears and asked to record urine odor. A kinetic-pharmacodynamic model characterized the data from both the newly conducted Takeda study (N = 42) and the previously analyzed American Society for Clinical Pharmacology and Therapeutics studies (total N = 139). The updated model included the identification of an absorption process with a half-life of 25 minutes. We estimated the elimination half-life of the asparagus effect on malodorous urine to be 7.2 hours, which was 44% longer in our study. We built on previous experience using an improved R-Shiny app for conducting the crowdsourcing experiment, further demonstrating the utility of this population kinetics approach in organizational and educational settings.
- Subjects :
- Male
Malodorous urine
Urinary system
Population
Urine
Article
Urine odor
law.invention
Random Allocation
law
Environmental health
Oils, Volatile
Humans
Plant Oils
Medicine
Pharmacology (medical)
Asparagus
education
education.field_of_study
Clinical pharmacology
biology
business.industry
Research
lcsh:RM1-950
Articles
biology.organism_classification
Healthy Volunteers
United States
Kinetics
lcsh:Therapeutics. Pharmacology
Odor
Modeling and Simulation
Population kinetics
Odorants
Crowdsourcing
Female
Asparagus Plant
business
Half-Life
Subjects
Details
- ISSN :
- 21638306
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- CPT: Pharmacometrics & Systems Pharmacology
- Accession number :
- edsair.doi.dedup.....9c49b0c3f69bdce3f4dafe238d5672f1