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Bariatric surgery reduces the risk of developing type 2 diabetes in severe obese subjects undergoing sleeve gastrectomy
- Source :
- Surgery for Obesity and Related Diseases. 15:168-172
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background Obesity is a major independent risk factor for developing type 2 diabetes (T2D). Objectives Our goal in this study was to analyze the impact of laparoscopic sleeve gastrectomy in the risk reduction of developing T2D in middle-aged, severely obese nondiabetes patients. Setting University Hospital, United States. Methods We retrospectively reviewed our prospectively collected database from 2010 to 2016. All severely obese patients between 45 and 64 years of age without diabetes at baseline that underwent sleeve gastrectomy were included in our study. The T2D risk score for predicting the incidence of diabetes was measured preoperatively and at 12 months postoperatively and was based on the Framingham Offspring Study that calculates an 8-year risk of developing T2D. Results Of the 1330 patients included in this study, 6.5% (n = 86) met the criteria for the T2D risk score calculation. The population was predominantly composed of females (68.9%; n = 59) with a mean age of 52.8 ± 5.3 years. Preoperative body mass index was 43.1 ± 6.9 kg/m2 with a percentage of estimated body mass index loss and percentages of total weight loss were 72.2 ± 26.3% and 26.39 ± 18.15%, respectively, with fasting plasma glucose of 103.3 ± 14.9 mg/dL. The preoperative risk for T2D was 13.9 ± 11.6%, with an absolute risk reduction 12 months after surgery of 10.3%, corresponding to a 74.2% relative risk reduction. When comparing between sexes, risk reduction in females was slightly better than in males; however, this was not statistically significant. At 12-month follow-up, all measured variables were significantly improved, except for diastolic blood pressure. Conclusions Laparoscopic sleeve gastrectomy significantly decreases the risk of developing T2D in middle-aged severely obese patients. Prospective studies are needed to further understand these findings.
- Subjects :
- Male
Relative risk reduction
medicine.medical_specialty
Sleeve gastrectomy
medicine.medical_treatment
Population
030209 endocrinology & metabolism
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Gastrectomy
Weight loss
Humans
Medicine
Risk factor
education
Retrospective Studies
education.field_of_study
Framingham Risk Score
business.industry
Absolute risk reduction
Middle Aged
Obesity, Morbid
Surgery
Treatment Outcome
Diabetes Mellitus, Type 2
Female
Laparoscopy
030211 gastroenterology & hepatology
medicine.symptom
business
Body mass index
Subjects
Details
- ISSN :
- 15507289
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Surgery for Obesity and Related Diseases
- Accession number :
- edsair.doi.dedup.....9c554f0074a2c174177073e4cc1b07d3