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The Bacterivore's Solution: Fight and Flight to Promote Survival
- Source :
- Developmental cell. 49(1)
- Publication Year :
- 2019
-
Abstract
- Mechanisms that control aging are important yet poorly defined. To discover longevity control genes, we performed a forward genetic screen for delayed reproductive aging in C. elegans. Here we show that am117 is a nonsense mutation in the phm-2 gene, which encodes a protein homologous to human scaffold attachment factor B. phm-2(lf) mutant worms have an abnormal pharynx grinder, which allows live bacteria to accumulate in the intestine. This defect shortens lifespan on highly pathogenic bacteria but extends lifespan and health span on the standard E. coli diet by activating innate immunity pathways that lead to bacterial avoidance behavior and dietary restriction. eat-2(lf) mutants displayed a similar phenotype, indicating accumulation of live bacteria also triggers extended longevity in this mutant. The analysis of phm-2 elucidates connections between pathogen response and aging by defining a mechanism of longevity extension in C. elegans - bacterial colonization, innate immune activation and bacterial avoidance behavior.
- Subjects :
- Bacterivore
Somatic cell
media_common.quotation_subject
Longevity
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Article
Microbiology
Fight-or-flight response
03 medical and health sciences
0302 clinical medicine
Bacterial colonization
medicine
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Molecular Biology
book
030304 developmental biology
media_common
0303 health sciences
Innate immune system
Developmental cell
Pathogenic bacteria
Cell Biology
Immunity, Innate
book.journal
030217 neurology & neurosurgery
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 18781551
- Volume :
- 49
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Developmental cell
- Accession number :
- edsair.doi.dedup.....9c66522375bf5c3320e9b976f0d93e5e