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Cognitive complaints in individuals recently diagnosed with bipolar disorder: A cross-sectional study

Cognitive complaints in individuals recently diagnosed with bipolar disorder: A cross-sectional study

Authors :
Thaíse Campos Mondin
Luciano Dias de Mattos Souza
Ricardo Azevedo da Silva
Taiane de Azevedo Cardoso
Benicio N. Frey
Igor Soares Vieira
Mario Simjanoski
Karen Jansen
Flávio Kapczinski
Fernanda Pedrotti Moreira
Source :
Psychiatry research. 300
Publication Year :
2020

Abstract

Aim To assess the differences in subjective cognitive dysfunction between major depressive disorder (MDD) and recently diagnosed Bipolar Disorder (BD) across euthymia and mood episodes. Methods This is a cross-sectional study corresponding to the second wave of a longitudinal study. The first wave consisted of subjects aged between 18 and 60 diagnosed with MDD. In the follow up after three years (second wave), conversion from MDD to BD diagnosis was assessed by qualified psychologists using the Mini International Neuropsychiatric Interview (MINI-Plus). Subjects were categorized in four diagnostic groups: euthymic MDD, MDD in a current mood episode, euthymic BD, and BD in a current mood episode. All subjects completed the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA), an instrument specifically designed for detecting subjective cognitive deficits in BD. Results The total sample (n = 468) included 410 subjects with MDD and 58 individuals recently diagnosed with BD. We subdivided the 2 groups based on their current mood state, and found a significant difference in COBRA total scores between euthymic BD individuals (median 17.00 [IQR: 8.75 - 20.75]) and euthymic MDD subjects (median 8.00 [IRQ: 5.00 - 14.00], p = 0.002), showing higher subjective cognitive dysfunction in individuals recently diagnosed with BD. The differences remained significant after adjusting for the presence of lifetime psychotic symptoms. We found no differences between MDD and BD during an acute mood episode. Limitation The small sample size of individuals with BD. Conclusion The findings suggest a higher presence of subjective cognitive complaints among individuals recently diagnosed with BD in comparison to individuals with MDD during euthymia.

Details

ISSN :
18727123
Volume :
300
Database :
OpenAIRE
Journal :
Psychiatry research
Accession number :
edsair.doi.dedup.....9c68f7ad35a9fb76cb64fc0a8b09e570