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Cognitive complaints in individuals recently diagnosed with bipolar disorder: A cross-sectional study
Cognitive complaints in individuals recently diagnosed with bipolar disorder: A cross-sectional study
- Source :
- Psychiatry research. 300
- Publication Year :
- 2020
-
Abstract
- Aim To assess the differences in subjective cognitive dysfunction between major depressive disorder (MDD) and recently diagnosed Bipolar Disorder (BD) across euthymia and mood episodes. Methods This is a cross-sectional study corresponding to the second wave of a longitudinal study. The first wave consisted of subjects aged between 18 and 60 diagnosed with MDD. In the follow up after three years (second wave), conversion from MDD to BD diagnosis was assessed by qualified psychologists using the Mini International Neuropsychiatric Interview (MINI-Plus). Subjects were categorized in four diagnostic groups: euthymic MDD, MDD in a current mood episode, euthymic BD, and BD in a current mood episode. All subjects completed the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA), an instrument specifically designed for detecting subjective cognitive deficits in BD. Results The total sample (n = 468) included 410 subjects with MDD and 58 individuals recently diagnosed with BD. We subdivided the 2 groups based on their current mood state, and found a significant difference in COBRA total scores between euthymic BD individuals (median 17.00 [IQR: 8.75 - 20.75]) and euthymic MDD subjects (median 8.00 [IRQ: 5.00 - 14.00], p = 0.002), showing higher subjective cognitive dysfunction in individuals recently diagnosed with BD. The differences remained significant after adjusting for the presence of lifetime psychotic symptoms. We found no differences between MDD and BD during an acute mood episode. Limitation The small sample size of individuals with BD. Conclusion The findings suggest a higher presence of subjective cognitive complaints among individuals recently diagnosed with BD in comparison to individuals with MDD during euthymia.
- Subjects :
- Adult
Longitudinal study
Bipolar Disorder
Adolescent
Cross-sectional study
behavioral disciplines and activities
03 medical and health sciences
Young Adult
0302 clinical medicine
Cognition
mental disorders
medicine
Humans
Bipolar disorder
Longitudinal Studies
Biological Psychiatry
Mini-international neuropsychiatric interview
Depressive Disorder, Major
business.industry
Middle Aged
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Mood
Cross-Sectional Studies
Mood disorders
Major depressive disorder
business
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- ISSN :
- 18727123
- Volume :
- 300
- Database :
- OpenAIRE
- Journal :
- Psychiatry research
- Accession number :
- edsair.doi.dedup.....9c68f7ad35a9fb76cb64fc0a8b09e570