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Adjuvant chemotherapy after radical nephroureterectomy does not improve survival in patients with upper tract urothelial carcinoma: a joint study by the European Association of Urology-Young Academic Urologists and the Upper Tract Urothelial Carcinoma Col
- Source :
- BJU International. 121:252-259
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objective: To analyse the outcomes of adjuvant chemotherapy vs observation in a multicentre cohort of patients with upper tract urothelial carcinoma (UTUC) in order to clarify whether such patients benefit from adjuvant chemotherapy after radical nephroureterectomy (RNU). Patients and Methods: Data from 15 centres were collected for a total of 1544 patients, treated between 2000 and 2015. Criteria for patient selection included pT2â4N0/x stage, or lymph node-positive disease, and prior RNU. The standardized difference approach was used to compare subgroup characteristics. Overall survival (OS) was the primary endpoint. The primary analysis used 1:1 propensity score matching, with inverse probability of treatment weighting in addition to this in the secondary analysis. The latter was also performed with the inclusion of covariates, i.e. with âdoubly robustâ estimation. A 6-month landmark analysis was performed to exclude early events. Results: A total of 312 patients received adjuvant chemotherapy and 1232 underwent observation. Despite differences between the two groups, the standardized difference was generally
- Subjects :
- Male
medicine.medical_specialty
Urology
030232 urology & nephrology
Disease
Nephroureterectomy
03 medical and health sciences
0302 clinical medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Clinical endpoint
Humans
Stage (cooking)
Pathological
propensity score
urothelial carcinoma
Aged
Retrospective Studies
Carcinoma, Transitional Cell
Ureteral Neoplasms
business.industry
Hazard ratio
nephroureterectomy
Retrospective cohort study
Middle Aged
Kidney Neoplasms
Survival Rate
adjuvant chemotherapy
upper tract
Chemotherapy, Adjuvant
Lymphatic Metastasis
030220 oncology & carcinogenesis
Propensity score matching
Cohort
Female
Cisplatin
business
Subjects
Details
- ISSN :
- 14644096
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- BJU International
- Accession number :
- edsair.doi.dedup.....9c7f6a62aad8f12636ece1f86ebf3c24