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Identical twins carry a persistent epigenetic signature of early genome programming
- Source :
- Nature communications, 12(1):5618. Nature Publishing Group, Nature Communications, Nature Communications, 12(1):5618, 1-14. Nature Publishing Group, Hemani, G 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618 . https://doi.org/10.1038/s41467-021-25583-7, Nature Communications, 12(1). NATURE PORTFOLIO, Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021), van Dongen, J, Gordon, S D, Odintsova, V V, Mbarek, H, Hagenbeek, F A, van Beijsterveldt, C E M, Jan Hottenga, J, de Geus, E J C, Willemsen, G, Boomsma, D I, Genetics of DNA Methylation Consortium & BIOS Consortium 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618, pp. 1-14 . https://doi.org/10.1038/s41467-021-25583-7, https://doi.org/10.1038/s41467-021-25583-7
- Publication Year :
- 2021
-
Abstract
- The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature in adult somatic tissues. Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs in families, the leading hypothesis is that it occurs at random. Here, we show that MZ twinning is strongly associated with a stable DNA methylation signature in adult somatic tissues. This signature spans regions near telomeres and centromeres, Polycomb-repressed regions and heterochromatin, genes involved in cell-adhesion, WNT signaling, cell fate, and putative human metastable epialleles. Our study also demonstrates a never-anticipated corollary: because identical twins keep a lifelong molecular signature, we can retrospectively diagnose if a person was conceived as monozygotic twin.<br />Netherlands Organization for Scientific Research (NWO); Biobanking and Biomolecular Research Infrastructure (BBMRI–NL); NWO Large Scale infrastructures; X-Omics
- Subjects :
- Epigenomics
Somatic cell
General Physics and Astronomy
Monozygotic twin
PROBE DESIGN BIAS
Genome
Epigenesis, Genetic
NORMALIZATION
0302 clinical medicine
Genetics research
Registries
Probe design bias
DNA methylation
Vanishing twin
Register
Cells
Normalization
Association
Ontology
Mothers
Family
112 Statistics and probability
Science and technology
Finland
Netherlands
0303 health sciences
Multidisciplinary
Zygote
Twinning, Monozygotic
MOTHERS
1184 Genetics, developmental biology, physiology
VANISHING TWIN
ASSOCIATION
Middle Aged
3142 Public health care science, environmental and occupational health
FAMILY
Multidisciplinary sciences
Embryogenesis
Adult
Genotype
Heterochromatin
Science
Quantitative Trait Loci
Biology
Polymorphism, Single Nucleotide
Article
General Biochemistry, Genetics and Molecular Biology
Young Adult
03 medical and health sciences
SDG 3 - Good Health and Well-being
Centromere
Humans
Epigenetics
Genetic epigenesis
REGISTER
Retrospective Studies
030304 developmental biology
3112 Neurosciences
Twins, Monozygotic
General Chemistry
United Kingdom
3141 Health care science
ONTOLOGY
Evolutionary biology
CELLS
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature communications, 12(1):5618. Nature Publishing Group, Nature Communications, Nature Communications, 12(1):5618, 1-14. Nature Publishing Group, Hemani, G 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618 . https://doi.org/10.1038/s41467-021-25583-7, Nature Communications, 12(1). NATURE PORTFOLIO, Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021), van Dongen, J, Gordon, S D, Odintsova, V V, Mbarek, H, Hagenbeek, F A, van Beijsterveldt, C E M, Jan Hottenga, J, de Geus, E J C, Willemsen, G, Boomsma, D I, Genetics of DNA Methylation Consortium & BIOS Consortium 2021, ' Identical twins carry a persistent epigenetic signature of early genome programming ', Nature Communications, vol. 12, no. 1, 5618, pp. 1-14 . https://doi.org/10.1038/s41467-021-25583-7, https://doi.org/10.1038/s41467-021-25583-7
- Accession number :
- edsair.doi.dedup.....9c8782e417f5a11b5e6694746e20eb68