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Primary vitreoretinal lymphoma: short review of the literature, results of a European survey and French guidelines of the LOC network for diagnosis, treatment and follow-up
- Source :
- Current Opinion in Oncology, Current Opinion in Oncology, 2021, 33 (5), pp.420-431. ⟨10.1097/cco.0000000000000776⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; Purpose of review. The aim of this study was to highlight the diagnostic and management challenges of primary vitreoretinal lymphoma (PVRL) through a review of the literature and a European survey on real-life practices for PVRL.Recent findings. The care of PVRL patients is heterogeneous between specialists and countries. Upfront systemic treatment based on highdose methotrexate chemotherapy, with or without local treatment, might reduce or delay the risk of brain relapse. Ibrutinib, lenalidomide with or without rituximab, and temozolomide are effective for patients with relapsed/refractory PVRL and should be tested as first-line treatments.Summary. The prognosis of PVRL remains dismal. No firm conclusion regarding optimal treatment can yet be drawn. The risk of brain relapse remains high. Diagnostic procedures and assessment of therapeutic responses need to be homogenized. Collaboration between specialists involved in PVRL and multicentric prospective therapeutic studies are strongly needed. The recommendations of the French group for primary oculocerebral lymphoma (LOC network) are provided, as a basis for further European collaborative work.
- Subjects :
- [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology
Cancer Research
medicine.medical_specialty
Lymphoma
Retinal Neoplasms
MEDLINE
[SDV.CAN]Life Sciences [q-bio]/Cancer
primary vitreoretinal lymphoma
[SDV.CAN] Life Sciences [q-bio]/Cancer
medicine
Humans
guidelines
Intensive care medicine
Lenalidomide
diagnosis and management challenges
Temozolomide
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
treatment
business.industry
European mapping
Optimal treatment
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
medicine.disease
Vitreous Body
Oncology
Diagnosis treatment
Rituximab
Neoplasm Recurrence, Local
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
medicine.drug
Vitreoretinal lymphoma
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 10408746
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Oncology, Current Opinion in Oncology, 2021, 33 (5), pp.420-431. ⟨10.1097/cco.0000000000000776⟩
- Accession number :
- edsair.doi.dedup.....9c8bc9018fc4e80776609a0eda60f821