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Comparison of the MK-801-induced increase in non-rewarded appetitive responding with dopamine agonists and locomotor activity in rats
- Source :
- Journal of psychopharmacology (Oxford, England). 27(9)
- Publication Year :
- 2013
-
Abstract
- Systemic administration of the noncompetitive N-methyl-D-aspartate (NMDA)- receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia. Evidence has shown that MK-801 increases the probability of operant responding during extinction, possibly modeling perseveration, as would be seen in patients with schizophrenia. This MK-801-induced behavioral perseveration is reversed by dopamine receptor antagonism. To further explore the role of dopamine in this behavioral change, the current study sought to determine if the MK-801-induced increase in non-rewarded operant responding could be mimicked by dopamine agonism and determine how it was related to locomotor activity. Male Long Evans rats were treated systemically with MK-801, cocaine, GBR12909 or apomorphine (APO) and given a single trial operant extinction session, followed by a separate assessment of locomotor activity. Both MK-801 (0.05 mg/kg) and cocaine (10 mg/kg) significantly increased responding during the extinction session and both increased horizontal locomotor activity. No dose of GBR-12909 (5, 10 or 20 mg/kg) was found to effect non-rewarded operant responding or locomotor activity. APO (0.05, 0.5, 2 or 5 mg/kg) treatment produced a dose-dependent decrease in both operant responding and locomotor activity. These results suggest the possibility that, rather than a primary influence of increased dopamine concentration on elevating bar-pressing responses during extinction, other neurotransmitter systems may be involved.
- Subjects :
- Male
medicine.medical_specialty
Apomorphine
medicine.drug_class
Perseveration
Dopamine
Motor Activity
Receptors, N-Methyl-D-Aspartate
Piperazines
Extinction, Psychological
Cocaine
Internal medicine
medicine
Animals
Pharmacology (medical)
Rats, Long-Evans
Pharmacology
Extinction (psychology)
Receptor antagonist
medicine.disease
Rats
Psychiatry and Mental health
Endocrinology
Dopamine receptor
Schizophrenia
Dopamine Agonists
NMDA receptor
medicine.symptom
Dizocilpine Maleate
Psychology
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 14617285
- Volume :
- 27
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of psychopharmacology (Oxford, England)
- Accession number :
- edsair.doi.dedup.....9ca0131ddf7b7a7c5a2a5136d0571e8c