Back to Search
Start Over
More Than Just a Weed: An Exploration of the Antimicrobial Activity of Rumex crispus using a Multivariate Data Analysis Approach
- Source :
- Planta medica. 88(9-10)
- Publication Year :
- 2023
-
Abstract
- Plants have a long history of use for their medicinal properties. The complexity of botanical extracts presents unique challenges and necessitates the application of innovative approaches to correctly identify and quantify bioactive compounds. For this study, we used untargeted metabolomics to explore the antimicrobial activity of Rumex crispus (yellow dock), a member of the Polygonaceae family used as an herbal remedy for bacterial infections. Ultra-performance liquid chromatography coupled with high resolution mass-spectrometry (UPLC-MS) was used to identify and quantify the known antimicrobial compound emodin. In addition, we used biochemometric approaches to integrate data measuring antimicrobial activity from R. crispus root starting material and fractions against methicillin-resistant Staphylococcus aureus (MRSA) with UPLC-MS data. Our results support the hypothesis that multiple constituents, including the anthraquinone emodin, contribute to the antimicrobial activity of R. crispus against MRSA.
- Subjects :
- Data Analysis
Methicillin-Resistant Staphylococcus aureus
Emodin
Pharmaceutical Science
High resolution
Polygonaceae
Analytical Chemistry
chemistry.chemical_compound
Tandem Mass Spectrometry
Drug Discovery
Rumex
Pharmacology
biology
Traditional medicine
Plant Extracts
Organic Chemistry
biology.organism_classification
Antimicrobial
Anti-Bacterial Agents
Untargeted metabolomics
Complementary and alternative medicine
chemistry
Molecular Medicine
History of use
Weed
Chromatography, Liquid
Subjects
Details
- ISSN :
- 14390221
- Volume :
- 88
- Issue :
- 9-10
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....9ca78ce5161383136c9e68a93ff69e1e