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Les effets des métabolites de l'imidaclopride sur l'accoutumance des abeilles suggèrent l'existence de deux sous-types de récepteurs nicotiniques ... l'expression différentielle durant le développement de l'adulte
- Source :
- Pharmacology Biochemistry and Behavior, Pharmacology Biochemistry and Behavior, Elsevier, 2003, 75, pp.217-222
- Publication Year :
- 2003
- Publisher :
- HAL CCSD, 2003.
-
Abstract
- Habituation of the proboscis extension reflex (PER) in honeybees (Apis mellifera) is age-dependent. Very young bees (or =7 days old) require significantly less trials to abolish the response to multiple sucrose stimulations than older bees (or =8 days old). A nicotinic agonist, imidacloprid, modifies this behaviour by increasing the number of trials inor =7-day-old bees and by decreasing it in older bees [Neurobiol. Learn. Mem. 76 (2001) 183.]. Here we tested our hypothesis that this effect is associated with a differential expression of two subtypes of nicotinic acetylcholine receptors (nAChRs). By testing the effects of six metabolites of imidacloprid, we show that two of them, olefin and 5-hydroxy-imidacloprid, modify the number of trials needed to habituate the PER in a contrasting manner. Olefin increases the number of trials in both age groups, whereas 5-hydroxy-imidacloprid decreases the number of trials, but only in 8-day-old individuals. We conclude that olefin and 5-hydroxy-imidacloprid are specific agonists of two subtypes of an nAChR that are differentially expressed during adult maturation of young honeybees. Olefin is the agonist of an nAChR expressed in both age groups, whereas 5-hydroxy-imidacloprid is the agonist of a late-onset nAChR that is activated in 8-day-old bees. The implications of this finding for the honeybee biology are discussed.
- Subjects :
- Agonist
Aging
medicine.drug_class
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Biology
Pharmacology
Alkenes
Receptors, Nicotinic
Toxicology
Biochemistry
APPRENTISSAGE
Behavioral Neuroscience
chemistry.chemical_compound
Neonicotinoids
Imidacloprid
parasitic diseases
medicine
Animals
Learning
Nicotinic Agonists
Habituation
Receptor
Habituation, Psychophysiologic
Biological Psychiatry
Biotransformation
abeille domestique
Acetylcholine receptor
Dose-Response Relationship, Drug
Neonicotinoid
Imidazoles
5-HYDROXY-IMIDACLOPRIDE
Bees
Nitro Compounds
[SDV] Life Sciences [q-bio]
Nicotinic agonist
Proboscis extension reflex
chemistry
IMIDACLOPRIDE
Subjects
Details
- Language :
- English
- ISSN :
- 00913057
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior, Pharmacology Biochemistry and Behavior, Elsevier, 2003, 75, pp.217-222
- Accession number :
- edsair.doi.dedup.....9cb9678fbcb195768ed9fb986bd7fe7f