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Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents
- Source :
- Drug Delivery, article-version (VoR) Version of Record, Drug Delivery, Vol 28, Iss 1, Pp 1562-1568 (2021)
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis, 2021.
-
Abstract
- The present study reports the generation of 2-hydroxyethyl starch microparticles for co-delivery and controlled release of multiple agents. The obtained microparticles are characterized by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. By using ofloxacin and ketoprofen as drug models, the release sustainability of the microparticles is examined at pH 1.2, 5.4, and 6.8 at 37 °C, with Fickian diffusion being found to be the major mechanism controlling the kinetics of drug release. Upon being loaded with the drug models, the microparticles show high efficiency in acting against Escherichia coli and Bacillus cereus. The results suggest that our reported microparticles warrant further development for applications in which co-administration of multiple bioactive agents is required.
- Subjects :
- Ketoprofen
Ofloxacin
ketoprofen
Starch
Chemistry, Pharmaceutical
Pharmaceutical Science
RM1-950
Hydroxyethyl starch
2-Hydroxyethyl starch
co-delivery
Hydroxyethyl Starch Derivatives
chemistry.chemical_compound
stomatognathic system
antibacterial activity
Bacillus cereus
medicine
Escherichia coli
sustained release
Particle Size
microparticles
Co delivery
Drug Carriers
Chromatography
Calorimetry, Differential Scanning
Chemistry
General Medicine
Hydrogen-Ion Concentration
Controlled release
Drug Liberation
Solubility
Therapeutics. Pharmacology
Antibacterial activity
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15210464 and 10717544
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Drug Delivery
- Accession number :
- edsair.doi.dedup.....9cc5ac3b909bfd5fe67de95481c5c680