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Clinical and Histologic Predictive Factors of Response to Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma
- Source :
- American Journal of Clinical Pathology. 146:546-553
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Objectives: Induction chemotherapy (IC) is occasionally used in head and neck cancer, leading to less extensive surgery and reduced need for irradiation. Factors predicting the response to IC have not been determined. In this study, we investigated the clinical and histopathologic factors that predict the response to IC. Methods: Head and neck squamous cell carcinomas from 81 patients were analyzed; clinical factors, histologic parameters, and expression of p16 and p53 were correlated with response to chemotherapy and prognosis. Results: Factors predicting a good response to IC were the nonoropharyngeal localization, a rich lymphocytic tissue response, and a low platelet-to-lymphocyte blood ratio before treatment. Response to IC did not correlate with prognosis, whereas a low neutrophil-to-lymphocyte ratio (NLR), the absence of a desmoplastic reaction, a rich lymphocytic tissue response, and the overexpression of p53 were associated with better prognosis. Conclusions: Lymphocytic tissue response, NLR, and nonoropharyngeal localization are factors predictive of response to IC.
- Subjects :
- Adult
Blood Platelets
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Pathology
Neutrophils
medicine.medical_treatment
Docetaxel
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
Lymphocytes
Cyclin-Dependent Kinase Inhibitor p16
Aged
Aged, 80 and over
Chemotherapy
business.industry
Head and neck cancer
Induction chemotherapy
Histology
Induction Chemotherapy
General Medicine
Middle Aged
Prognosis
medicine.disease
Chemotherapy regimen
Head and neck squamous-cell carcinoma
030104 developmental biology
Lymphatic system
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Immunohistochemistry
Female
Taxoids
Fluorouracil
France
Cisplatin
Tumor Suppressor Protein p53
business
Subjects
Details
- ISSN :
- 19437722 and 00029173
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....9cdbbeffc1d1f6d0d9c3b3a79c3e3500