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Carbohydrate-based vaccines for oncotherapy
- Source :
- Medicinal research reviews. 38(3)
- Publication Year :
- 2017
-
Abstract
- Cancer is still one of the most serious threats to human worldwide. Aberrant patterns of glycosylation on the surface of cancer cells, which are correlated with various cancer development stages, can differentiate the abnormal tissues from the healthy ones. Therefore, tumor-associated carbohydrate antigens (TACAs) represent the desired targets for cancer immunotherapy. However, these carbohydrate antigens may not able to evoke powerful immune response to combat with cancer for their poor immunogenicity and immunotolerance. Different approaches have been developed to address these problems. In this review, we want to summarize the latest advances in TACAs based anticancer vaccines.
- Subjects :
- medicine.medical_treatment
010402 general chemistry
01 natural sciences
Cancer Vaccines
Translational Research, Biomedical
Immune system
Antigen
Cancer immunotherapy
Drug Discovery
medicine
Animals
Humans
Antigens, Tumor-Associated, Carbohydrate
Pharmacology
010405 organic chemistry
business.industry
Immunogenicity
Cancer
Immunotherapy
medicine.disease
0104 chemical sciences
Cancer cell
Cancer research
Molecular Medicine
Nanoparticles
Cancer vaccine
business
Subjects
Details
- ISSN :
- 10981128
- Volume :
- 38
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Medicinal research reviews
- Accession number :
- edsair.doi.dedup.....9ce7b6aaa590575198d54464809dd734