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Metastatic Head and Neck Malignancy Treated Using MRI Guided Interstitial Laser Phototherapy
Metastatic Head and Neck Malignancy Treated Using MRI Guided Interstitial Laser Phototherapy
- Source :
- The Laryngoscope. 102:26
- Publication Year :
- 1992
- Publisher :
- Wiley, 1992.
-
Abstract
- Interstitial laser phototherapy (ILP) guided by magnetic resonance imaging (MRI) may become an attractive adjunctive modality for the treatment of deep and surgically inaccessible tumors of the head and neck when accurate methods of laser dosimetry and "real-time" monitoring techniques with the MRI are introduced. We recently demonstrated in ex vivo and in vivo models, a linear relationship between levels of laser energies, thermal profiles, MR signal intensity changes, and histopathological tissue damage. Results of treatment in a patient with an unresectable large right jugulodigastric metastatic squamous carcinoma using new approach of MRI guided ILP are now reported. The patient complained of significant right-sided neck pain and headaches secondary to a rapidly growing metastatic lymphadenopathy which recurred after previous surgery, radiation, and chemotherapy. Two treatment sessions were used at an interval of 2 weeks. Each treatment was performed in the MRI suite under heavy sedation. Using a 600-microns bare fiber of the Nd:YAG laser implanted interstitially under MR guidance, the metastatic node was treated at three sites. T1- and T2-weighted images were performed prior to, immediately after, 24 and 48 hours, and 4, 5, 7, 9, 16, and 25 days post-treatment. Successful relief of pain and growth arrest of this node was observed after the second treatment and at the 3-month follow-up. These results demonstrate that this technique of ILP guided by MRI may be feasible in humans, and will become clinically practical when appropriate methods of dosimetry and instrumentation are developed.
- Subjects :
- Sedation
Light Coagulation
Malignancy
Catheterization
Metastasis
medicine
Humans
Dosimetry
Neoplasm Invasiveness
Yttrium
Laryngeal Neoplasms
Neodymium
Neck pain
medicine.diagnostic_test
business.industry
Palliative Care
Magnetic resonance imaging
Middle Aged
medicine.disease
Combined Modality Therapy
Magnetic Resonance Imaging
Squamous carcinoma
Otorhinolaryngology
Head and Neck Neoplasms
Lymphatic Metastasis
Carcinoma, Squamous Cell
Aluminum Silicates
Female
medicine.symptom
Headaches
business
Nuclear medicine
Subjects
Details
- ISSN :
- 0023852X
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- The Laryngoscope
- Accession number :
- edsair.doi.dedup.....9cf1a6c36f011dcdad0ebd9348fcf948
- Full Text :
- https://doi.org/10.1288/00005537-199201000-00005