Do hospital workers experience a higher risk of respiratory symptoms and loss of lung function?

Background: The hospital work environment contains various biological and chemical exposures that can affect indoor air quality and have impact on respiratory health of the staff. The objective of this study was to investigate potential effects of occupational exposures on the risk of respiratory symptoms and lung function in hospital work, and to evaluate potential interaction between smoking and occupational exposures.Methods: We conducted a cross-sectional study of 228 staff members in a hospital and 228 employees of an office building as the reference group in Shiraz, Iran. All subjects completed a standardized respiratory ATS questionnaire and performed a spirometry test. Results: In Poisson regression, the adjusted prevalence ratios (aPR) among the hospital staff were elevated for cough (aPR 1.90, 95% CI: 1.15, 3.16), phlegm production (aPR 3.21, 95% CI: 1.63, 6.32), productive cough (aPR 2.83, 95% CI: 1.48, 5.43), wheezing (aPR 3.18, 95% CI: 1.04, 9.66), shortness of breath (aPR 1.40, 95% CI: 0.93, 2.12), and chest tightness (aPR 1.73, 95% CI: 0.73, 4.12). Particularly laboratory personnel experienced increased risk of most symptoms. In linear regression adjusting for confounding, there were no significant differences in lung function between the hospital and office workers. There was an indication of synergism between hospital exposures and current smoking on FEV1/FVC% (β = -5.37, 95%CI: -10.27, -0.47).Conclusions: This study provides evidence that hospital work, especially in laboratories, increases the risk of respiratory symptoms. Smoking appears to enhance these effects considerably. Our findings suggest that policymakers should implement evidence-based measures to prevent these occupational exposures.