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lncRNA CASC11 promotes cancer cell proliferation in bladder cancer through miRNA‐150
- Source :
- Journal of Cellular Biochemistry
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- Long noncoding RNAs (lncRNAs) CASC11 is an oncogenic lncRNA in gastric cancer and colorectal cancer. Our study aimed to investigate the role of lncRNA CASC11 in bladder cancer. In this study we showed that plasma lncRNA CASC11 was upregulated, while plasma miRNA‐150 was downregulated in patients with early‐stage bladder cancer than in healthy controls. Altered expression of plasma lncRNA CASC11 and miRNA‐150 separated patients with bladder cancer from healthy controls. lncRNA CASC11 expression was inversely correlated with miRNA‐150 expression in patients with bladder cance but not in healthy controls. Overexpression of lncRNA CASC11 mediated the inhibition of miRNA‐150 expression in cancer cells, while miRNA‐150 overexpression did not significantly alter lncRNA CASC11 expression. lncRNA CASC11 overexpression promoted, while miRNA‐150 overexpression inhibited cancer cell proliferation. miRNA‐150 also attenuated the enhancing effects of lncRNA CASC11 overexpression on cancer cell proliferation. However, overexpression of lncRNA CASC11 showed no significant effects on cancer cell migration and invasion. Therefore, lncRNA CASC11 may promote cancer cell proliferation in bladder cancer, and the actions of lncRNA CASC11 are likely through miRNA‐150.
- Subjects :
- 0301 basic medicine
Adult
Male
Colorectal cancer
diagnosis
Biochemistry
long noncoding RNA CASC11
miRNA‐150
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Cell Movement
Cell Line, Tumor
microRNA
medicine
Humans
Molecular Biology
Research Articles
Aged
Bladder cancer
business.industry
Cell growth
Cancer cell proliferation
Cancer
Cell Biology
Middle Aged
medicine.disease
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
cell proliferation
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Cancer cell
Cancer research
bladder cancer
Female
RNA, Long Noncoding
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 10974644 and 07302312
- Volume :
- 120
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Biochemistry
- Accession number :
- edsair.doi.dedup.....9d364968a9a8055924335e6c07327ade