Back to Search
Start Over
Broad clinical spectrum and diverse outcomes of prolactinoma with pediatric onset: medication-resistant and recurrent cases
Broad clinical spectrum and diverse outcomes of prolactinoma with pediatric onset: medication-resistant and recurrent cases
- Source :
- Endocrine journal. 65(3)
- Publication Year :
- 2017
-
Abstract
- Prolactinoma is a benign tumor of the pituitary gland that rarely occurs in children and adolescents; thus, the clinical spectrum and long-term prognosis in these patients remain unknown. This study was performed to investigate the long-term outcomes of medical treatment and the prognostic factors for remission and relapse in children and adolescents with prolactinoma. Three male subjects and four female subjects between the ages of 7- and 17-years-old were included in this study. The mean initial serum prolactin level was 443 ± 251.8 ng/mL (range, 152-946 ng/mL). During the follow-up period (range, 0.6-20 years), a dopamine agonist was administered, and surgery or radiotherapy was performed in cases of resistance to medical treatment or relapse. Unlike female subjects with macroadenoma who often exhibit a good clinical course, two male subjects with early onset macroadenoma presented with visual disturbances. These subjects showed resistance to medical therapy and relapsed, eventually requiring surgical removal and radiotherapy; one of the subjects manifested a metastatic thrombus in the internal jugular vein. In conclusion, pediatric prolactinoma exhibits a broad clinical spectrum, a relatively high incidence of macroadenoma, resistance to medical therapy, and frequent tumor relapses. In addition, a poor prognosis appears to be correlated with male sex, age at disease onset, and histopathological characteristics.
- Subjects :
- Male
Pituitary gland
Pediatrics
medicine.medical_specialty
Adolescent
Pediatric onset
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Dopamine agonist
Benign tumor
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex Factors
medicine
Humans
Pituitary Neoplasms
Prolactinoma
Thrombus
Age of Onset
Child
Internal jugular vein
Retrospective Studies
business.industry
medicine.disease
Prognosis
Prolactin
Radiation therapy
medicine.anatomical_structure
Dopamine Agonists
Female
Neoplasm Recurrence, Local
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 13484540
- Volume :
- 65
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Endocrine journal
- Accession number :
- edsair.doi.dedup.....9d3943f1c9a2ee1f5eab3df9968c56d6