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The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease
- Source :
- Alimentary Pharmacology & Therapeutics. 9:547-552
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- SUMMARY Background: Recent studies have shown both interleukin 2 (IL-2) and interferon gamma (IFN) to be elevated in patients with active Crohn's disease compared to ulcerative colitis or non-inflammatory bowel disease controls. However the effect of treatment on these lymphokines has not been studied. Patients and methods: Using a reverse haemolytic plaque assay the percentage of lymphokine-secreting cells was determined in the intestinal mucosa of children with Crohn's disease before and after 8 weeks of treatment with either enteral nutrition, cyclosporin or steroids. Results: Before treatment, a high percentage of cells isolated from mucosal biopsies secreted IL-2 or interferon-gamma. Eight weeks’treatment with the immunosuppressive agents cyclosporin, or with corticosteroids, produced a significant reduction in the percentage of IL-2 secreting cells, although only for the former was there also a reduction in interferon-gamma secreting cells. Enteral nutrition however, produced a reduction in lymphokine-secreting cells equivalent to cyclosporin and produced the best histological and clinical improvement. Conclusion: Enteral nutrition and cyclosporin can down-regulate lymphokine secretion in the gut in Crohn's disease.
- Subjects :
- Male
Cellular immunity
medicine.medical_specialty
Adolescent
Prednisolone
T-Lymphocytes
medicine.medical_treatment
Anti-Inflammatory Agents
Down-Regulation
Enteral administration
Gastroenterology
Interferon-gamma
Enteral Nutrition
Crohn Disease
Intestinal mucosa
Internal medicine
medicine
Humans
Pharmacology (medical)
Interferon gamma
Intestinal Mucosa
Child
Crohn's disease
Hepatology
business.industry
Biopsy, Needle
Lymphokine
medicine.disease
Ulcerative colitis
Cytokine
Immunology
Cyclosporine
Interleukin-2
Female
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 13652036 and 02692813
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....9d3bd8e254a111e4840dd34e434e6912