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Human KIT+ myeloid cells facilitate visceral metastasis by melanoma
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2021
- Publisher :
- Rockefeller University Press, 2021.
-
Abstract
- Colonization of visceral organs with melanoma in humanized NSG-SGM3 mice is dependent upon human CD33+CD11b+CD117+ progenitor cells. A gene signature of KIT/CD117–expressing CD33+ subset correlates with decreased overall survival in TCGA melanoma samples and represents a novel candidate biomarker.<br />Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice that colonization of distant visceral organs with melanoma is dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising<br />Graphical Abstract
- Subjects :
- Tumor Immunology
0301 basic medicine
Innate Immunity and Inflammation
Immunology
CD33
Metastasis
Cohort Studies
Mice
03 medical and health sciences
0302 clinical medicine
Mice, Inbred NOD
Cell Line, Tumor
Leukocytes
Animals
Humans
Immunology and Allergy
Medicine
Myeloid Cells
Progenitor cell
Melanoma
CD11b Antigen
biology
CD117
business.industry
Brief Definitive Report
Prognosis
medicine.disease
digestive system diseases
Gene expression profiling
Proto-Oncogene Proteins c-kit
030104 developmental biology
030220 oncology & carcinogenesis
biology.protein
Cancer research
Leukocyte Common Antigens
Biomarker (medicine)
Stem cell
business
Biomarkers
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 218
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....9d5aaf2d762d8d09d77fb655a3f8f427
- Full Text :
- https://doi.org/10.1084/jem.20182163