Hypoxia promotes glycogen synthesis and accumulation in human ovarian clear cell carcinoma

Authors :: Katsuhiko Aoki
Nozomu Yanaihara
Kazu Ueda
Kiyoshi Ohkawa
Tadashi Asakura
Aikou Okamoto
Yasushi Iida
Tadao Tanaka
Kyosuke Yamada
Satoshi Takakura
Source :: International Journal of Oncology.
Publication Year :: 2012
Publisher :: Spandidos Publications, 2012.
Abstract: Ovarian clear cell carcinoma (OCCC) has several significant characteristics based on molecular features that are distinct from those of ovarian high-grade serous carcinoma. Cellular glycogen accumulation is the most conspicuous feature of OCCC and in the present study its metabolic mechanism was investigated. The amount of glycogen in cells cultured under hypoxia increased significantly and approximately doubled after 48 h (P

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