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Superficial adenocarcinoma of the oesophagus arising in Barrett's mucosa with dysplasia: a clinico-pathological study of 12 patients
- Source :
- Histopathology. 16:213-220
- Publication Year :
- 1990
- Publisher :
- Wiley, 1990.
-
Abstract
- Superficial adenocarcinoma of the oesophagus is defined as carcinoma limited to the mucosa or submucosa regardless of lymph node status. Columnar epithelium lined lower oesophagus, now generally referred to as Barrett's oesophagus, is probably the main cause of adenocarcinoma in the lower oesophagus. Twelve cases of superficial adenocarcinoma arising in Barrett's oesophagus are presented. They were observed over a 6 year period and taken from a series of 50 cases of patients with Barrett's oesophagus and adenocarcinoma, a prevalence of 24%. Endoscopic diagnosis of malignancy was made in six patients. The initial biopsies showed an adenocarcinoma in six patients and some degrees of dysplasia in the other six patients. Prior to surgery, a histological diagnosis of adenocarcinoma was made in all twelve patients. In four patients the adenocarcinoma was confined to the mucosa, and in eight it extended to the submucosa. One patient had a metastatic lymph node. Ten patients are alive without evidence of tumour spread after a mean follow-up of 30 months.
- Subjects :
- Adult
Male
medicine.medical_specialty
Histology
Esophageal Neoplasms
Biopsy
Adenocarcinoma
Malignancy
digestive system
Gastroenterology
Pathology and Forensic Medicine
Barrett Esophagus
Internal medicine
Submucosa
medicine
Carcinoma
Humans
Barrett's mucosa
Lymph node
Aged
business.industry
digestive, oral, and skin physiology
General Medicine
Middle Aged
medicine.disease
digestive system diseases
medicine.anatomical_structure
Dysplasia
Female
Clinico pathological
business
Subjects
Details
- ISSN :
- 13652559 and 03090167
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Histopathology
- Accession number :
- edsair.doi.dedup.....9d8b96aa0c09be1af6153e78b263f89d