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High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis
- Source :
- Journal of Surgical Oncology. 94:413-417
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Background and Objectives Although elective neck dissection has become a popular treatment modality for early oral cancer among most head and neck surgeons, a large portion of patients revealed pathological N0 postoperatively. Our study is aimed to evaluate the expressions of the angiogenic factors, vascular endothelial growth factor (VEGF), and CD105 (endoglin) on the prediction of neck metastasis for clinical N0 patients in early oral cancer. Patients and Methods Between July 1996 and July 2005, the preoperative biopsy specimens among 176 patients who underwent surgical treatment for early oral cancer were retrieved for the immunohistochemical study for VEGF and CD105. Results High expressions of CD105 and VEGF significantly correlated with positive nodal metastasis, respectively (P
- Subjects :
- Vascular Endothelial Growth Factor A
Oncology
medicine.medical_specialty
Pathology
Angiogenesis
medicine.medical_treatment
Receptors, Cell Surface
Sensitivity and Specificity
Metastasis
chemistry.chemical_compound
Antigens, CD
Internal medicine
Biomarkers, Tumor
medicine
Humans
Survival rate
Pathological
Analysis of Variance
business.industry
Endoglin
Cancer
Neck dissection
General Medicine
Prognosis
medicine.disease
Immunohistochemistry
Survival Rate
Vascular endothelial growth factor
chemistry
Head and Neck Neoplasms
Lymphatic Metastasis
Mouth Neoplasms
Surgery
Lymph Nodes
business
Forecasting
Subjects
Details
- ISSN :
- 10969098 and 00224790
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....9d8ce5967a71c05e6dcf1a501bccc9f6