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Stress and the Gut-Brain Axis: Implications for Cancer, Inflammation and Sepsis
- Source :
- The Journal of surgical research. 266
- Publication Year :
- 2020
-
Abstract
- Background The gut-brain axis has been discussed, directly or indirectly, for centuries, with the ideas of the gut affecting anything from moods to overall physiology being discussed across the centuries. With a recent explosion in research that looks to the microbiota as a mechanistic link between the gut and the brain, one sees that the gut-brain axis has various means of communication, such as through the vagus nerve and the enteric nervous system and can use the metabolites in the gut to communicate to the brain. Methods The purpose of this review is to view the gut-brain axis through the lens of stress and how stress, from the prenatal period all the way through adulthood can impact the physiology of a human being. Studies have shown multiple mechanisms of measurable change with disruption in the microbiota that lead to behavioral changes. There are also effects of gut inflammation on the brain and the corresponding systemic response observed. Conclusion The overall literature is encouraging that the more understanding of the gut-brain axis, the greater ability to wield that understanding for therapeutic benefits.
- Subjects :
- Gut inflammation
Gut–brain axis
Inflammation
digestive system
Enteric Nervous System
Sepsis
03 medical and health sciences
0302 clinical medicine
Pregnancy
Neoplasms
medicine
Humans
business.industry
digestive, oral, and skin physiology
Cancer
Brain
Vagus Nerve
medicine.disease
Human being
Vagus nerve
Gastrointestinal Microbiome
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Surgery
Enteric nervous system
Female
medicine.symptom
business
Neuroscience
Stress, Psychological
Subjects
Details
- ISSN :
- 10958673
- Volume :
- 266
- Database :
- OpenAIRE
- Journal :
- The Journal of surgical research
- Accession number :
- edsair.doi.dedup.....9d9a254235e3a2495d1feabdb5bab341