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HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan
HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan
- Source :
- Journal of acquired immune deficiency syndromes (1999). 75(5)
- Publication Year :
- 2017
-
Abstract
- Background HIV can cause an imbalance of T lymphocytes, which may contribute to the onset of psoriasis. However, the association of HIV with incident psoriasis has not been extensively studied. Objectives The aim of this nationwide population-based cohort study was to determine the association of HIV with incident psoriasis. Methods Since January 1, 2000, we identified adult people living with HIV/AIDS (PLWHA) from the Taiwan National Health Insurance Research Database. A control cohort without HIV infection, matched for age and sex, was selected for comparison. All patients were followed until December 31, 2012, and observed for the occurrence of psoriasis. The time-dependent Cox proportional hazards model was used to determine the association of HIV with incident psoriasis, while considering death as a competing risk event. Results Of the 102,070 patients (20,294 PLWHA and 81,776 matched controls), 248 (0.24%) had incident psoriasis during a mean follow-up period of 5.53 years, including 81 (0.40%) PLWHA and 171 (0.21%) controls. After adjusting for age, sex, and comorbidities, HIV infection was found to be an independent risk factor for incident psoriasis (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38 to 2.36). Conclusions The population of PLWHA is living longer; clinicians need to be aware of their higher risk of psoriasis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
T-Lymphocytes
Population
CD4-CD8 Ratio
Taiwan
HIV Infections
030207 dermatology & venereal diseases
03 medical and health sciences
Young Adult
0302 clinical medicine
Acquired immunodeficiency syndrome (AIDS)
Risk Factors
Internal medicine
Psoriasis
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Risk factor
education
Proportional Hazards Models
education.field_of_study
Proportional hazards model
business.industry
Incidence
Hazard ratio
Middle Aged
medicine.disease
Infectious Diseases
Population Surveillance
Cohort
Female
business
Cohort study
Follow-Up Studies
Subjects
Details
- ISSN :
- 19447884
- Volume :
- 75
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Accession number :
- edsair.doi.dedup.....9daa82db6764983659debd10fbf2e550