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Serum enzymes of lysosomal origin as indicators of the metabolic control in non-insulin-dependent diabetics
- Source :
- Acta Diabetologica Latina. 24:331-340
- Publication Year :
- 1987
- Publisher :
- Springer Science and Business Media LLC, 1987.
-
Abstract
- Several lysosomal enzymes (beta-N-acetyl-D-glucosaminidase, beta-D-glucuronidase, alpha-D-galactosidase, beta-D-galactosidase, alpha-D-glucosidase, beta-D-glucosidase, alpha-L-fucosidase and alpha-D-mannosidase) were determined in the serum of 54 non-insulin-dependent diabetics with different degrees of metabolic control and without complications and in 18 non-insulin-dependent diabetics with complications. The serum levels of beta-N-acetyl-D-glucosaminidase, beta-D-glucuronidase, alpha-D-galactosidase, and alpha-D-mannosidase were significantly (p less than 0.01) higher in the diabetics without complications. The levels of beta-N-acetyl-D-glucosaminidase and beta-D-glucuronidase were inversely proportional to the degree of metabolic control, in a statistically significant manner. Moreover the levels of these enzymes decreased to normal values during a 2-month period of controlled oral hypoglycemic drug-diet therapy resulting in metabolic compensation. The presence of complications was indicated by a further increase of serum beta-N-acetyl-D-glucosaminidase and beta-D-glucuronidase; however the portion of lysosomal enzyme activities due to complications remained unchanged after controlled therapy aimed at compensating the metabolism. The conclusion is drawn that in non-insulin-dependent diabetics, as already shown for insulin dependent-diabetics, serum lysosomal enzymes, especially beta-N-acetyl-D-glucosaminidase and beta-D-glucuronidase, are good intraindividual indicators of the metabolic control of the disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Normal values
Biology
Serum enzymes
Endocrinology
alpha-Mannosidase
Diabetes mellitus
Internal medicine
Mannosidases
Internal Medicine
medicine
Humans
Longitudinal Studies
Aged
chemistry.chemical_classification
beta-Glucosidase
Insulin
Non insulin dependent diabetes mellitus
General Medicine
Metabolism
Middle Aged
beta-Galactosidase
medicine.disease
Enzyme
Diabetes Mellitus, Type 2
chemistry
Metabolic control analysis
Female
Lysosomes
Subjects
Details
- ISSN :
- 14325233 and 00015563
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica Latina
- Accession number :
- edsair.doi.dedup.....9db5087b1dc81a5e859f6c020e58ca2d
- Full Text :
- https://doi.org/10.1007/bf02742966