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Maternally Derived Recombinant Human Anti-Hantavirus Monoclonal Antibodies Are Transferred to Mouse Offspring during Lactation and Neutralize Virus In Vitro
- Source :
- Journal of Virology
- Publication Year :
- 2006
- Publisher :
- American Society for Microbiology, 2006.
-
Abstract
- Transgenic mice expressing a recombinant human monoclonal antibody (rHMAb) against hantavirus were generated. These mice could be used as models to explore the possibilities of producing rHMAbs for therapeutic purposes. The highest concentration of the rHMAb in the milk of the transgenic females was 6.6 mg/ml. The rHMAb was also detected in the sera of pups fed by the transgenic females. Both the rHMAbs in the milk of transgenic mice and those in the sera of suckling pups were found to be active against hantaviruses, although the light chain of the antibody absorbed by the pups was modified by N-linked glycosylation.
- Subjects :
- Genetically modified mouse
Orthohantavirus
medicine.drug_class
Transgene
Immunology
Fluorescent Antibody Technique
Mice, Transgenic
Antibodies, Viral
Monoclonal antibody
Microbiology
Virus
law.invention
Mice
law
Virology
Lactation
medicine
Animals
Hantavirus
biology
Antibodies, Monoclonal
Recombinant Proteins
Milk
medicine.anatomical_structure
Insect Science
Recombinant DNA
biology.protein
Pathogenesis and Immunity
Female
Antibody
Immunity, Maternally-Acquired
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....9df2b4694074824ba95c94f70530e1a7