Additional file 1: of Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy

Figure S1. Immune reactivity of H-Zt/g4 to RON in multiple tissues from human and cynomolgus monkey. Figure S2. Effect of H-Zt/g4-MMAE on eradication of RON-expressing cells in PDAC xenograft tumors. Figure S3. Induction in vitro by H-Zt/g4-MMAE of death of PDAC stem-like cells. Figure S4. Effect of H-Zt/g4-MMAE on elimination of RON-expressing cells in PSC + 24/44/ESA cell-mediated xenografts. Figure S5A. Cell surface RON expression by a panel of primary PDX cell lines. Figure S5B. Induction of cell surface RON internalization by H-Zt/g4. Figure S5C. Effect of H-Zt/g4-MMAE on viability of primary PDAC cell lines derived from patient’ tumors. Figure S6. Histological examination of multiple organs and/or tissues from cynomolgus monkey treated with H-Zt/g4-MMAE. Figure S7. Histological examination of multiple organs and/or tissues from cynomolgus monkey treated with H-Zt/g4-MMAE. (PDF 2315 kb)