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Tandem Michael addition/ylide epoxidation for the synthesis of highly functionalized cyclohexadiene epoxide derivatives
- Source :
- Journal of the American Chemical Society. 130(16)
- Publication Year :
- 2008
-
Abstract
- A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields.
Details
- ISSN :
- 15205126
- Volume :
- 130
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....9e2aafe384ce7512f8dea2810605059b