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The effect of Pluronic F-68 on hybridoma cells in continuous culture
- Source :
- Applied Microbiology and Biotechnology. 37
- Publication Year :
- 1992
- Publisher :
- Springer Science and Business Media LLC, 1992.
-
Abstract
- The comparative effects of Pluronic on cell growth of hybridomas were studied. The addition of 0.05% Pluronic decreased the steady-state cell number in continuous culture by about 12% compared to a non-supplemented culture. In short-term experiments, results demonstrated a gradual decrease in cell number with increasing concentration of Pluronic. Such growth inhibition was found to be a result of lowering the rate of DNA synthesis.
- Subjects :
- Hybridomas
Dose-Response Relationship, Drug
DNA synthesis
Cell growth
Cell number
General Medicine
Poloxamer
Biology
Applied Microbiology and Biotechnology
Molecular biology
Mice
chemistry.chemical_compound
chemistry
Biochemistry
Cell culture
Animals
Poloxalene
Growth inhibition
Cells, Cultured
Biotechnology
Subjects
Details
- ISSN :
- 14320614 and 01757598
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Applied Microbiology and Biotechnology
- Accession number :
- edsair.doi.dedup.....9e2edb40d8dc8e7691298a5d0b49eaed
- Full Text :
- https://doi.org/10.1007/bf00174201