Back to Search Start Over

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

Authors :
Katharina Brosch
Frederike Stein
Simon Schmitt
Julia-Katharina Pfarr
Kai G. Ringwald
Florian Thomas-Odenthal
Tina Meller
Olaf Steinsträter
Lena Waltemate
Hannah Lemke
Susanne Meinert
Alexandra Winter
Fabian Breuer
Katharina Thiel
Dominik Grotegerd
Tim Hahn
Andreas Jansen
Udo Dannlowski
Axel Krug
Igor Nenadić
Tilo Kircher
Source :
Molecular psychiatry. 27(10)
Publication Year :
2021

Abstract

Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk factors, genetics, and other biological measures. Based on previous findings, it remains unclear what transdiagnostic regional gray matter volume (GMV) alterations exist across these disorders, and with which factors they are associated. GMV (3-T magnetic resonance imaging) was compared between healthy controls (HC; n = 110), DSM-IV-TR diagnosed MDD (n = 110), BD (n = 110), and SSD patients (n = 110), matched for age and sex. We applied a conjunction analysis to identify shared GMV alterations across the disorders. To identify potential origins of identified GMV clusters, we associated them with early and current risk and protective factors, psychopathology, and neuropsychology, applying multiple regression models. Common to all diagnoses (vs. HC), we identified GMV reductions in the left hippocampus. This cluster was associated with the neuropsychology factor working memory/executive functioning, stressful life events, and with global assessment of functioning. Differential effects between groups were present in the left and right frontal operculae and left insula, with volume variances across groups highly overlapping. Our study is the first with a large, matched, transdiagnostic sample to yield shared GMV alterations in the left hippocampus across major mental disorders. The hippocampus is a major network hub, orchestrating a range of mental functions. Our findings underscore the need for a novel stratification of mental disorders, other than categorical diagnoses.

Details

ISSN :
14765578
Volume :
27
Issue :
10
Database :
OpenAIRE
Journal :
Molecular psychiatry
Accession number :
edsair.doi.dedup.....9e3db1ade23f137bd9efe04695544c77