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Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
- Source :
- Nat Neurosci
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in TAMs to modulate their function and T cell immunity. AHR promotes CCR2 expression, driving TAM recruitment in response to CCL2. AHR also drives the expression of KLF4 and suppresses NF-κB activation in TAMs. Finally, AHR drives the expression of the ectonucleotidase CD39 in TAMs, which promotes CD8
- Subjects :
- STAT3 Transcription Factor
0301 basic medicine
T-Lymphocytes
Lipopolysaccharide Receptors
MEDLINE
Mice, Transgenic
Bioinformatics
Article
Kruppel-Like Factor 4
03 medical and health sciences
0302 clinical medicine
Text mining
Antigens, CD
Cell Line, Tumor
Tumor Microenvironment
medicine
Animals
Humans
Kynurenine
Brain Neoplasms
business.industry
Macrophages
General Neuroscience
Published Erratum
Apyrase
medicine.disease
Mice, Inbred C57BL
MicroRNAs
STAT1 Transcription Factor
030104 developmental biology
Receptors, Aryl Hydrocarbon
Disease Progression
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Glioblastoma
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15461726 and 10976256
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Nature Neuroscience
- Accession number :
- edsair.doi.dedup.....9e4859869df4eccdefe630c6ccba688e
- Full Text :
- https://doi.org/10.1038/s41593-019-0446-8