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Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Authors :
Ivan D. Mascanfroni
David A. Reardon
Jack P. Antel
Gad Getz
Luke M. Healy
Francisco J. Quintana
Mauricio F. Farez
Veit Rothhammer
Maisa C. Takenaka
Michael A. Wheeler
Cristina Gutiérrez-Vázquez
Hailei Zhang
Jessica E. Kenison
Simon C. Robson
Lior Mayo
Soufiene Ghannam
Chun-Cheih Chao
Kalil Alves de Lima
Tyler Vandeventer
Sonja Rothweiler
Emily C. Tjon
David H. Sherr
Howard L. Weiner
Alexandre Prat
Galina Gabriely
Stephanie Zandee
Andreia Barroso
Source :
Nat Neurosci
Publication Year :
2019
Publisher :
Springer Science and Business Media LLC, 2019.

Abstract

Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in TAMs to modulate their function and T cell immunity. AHR promotes CCR2 expression, driving TAM recruitment in response to CCL2. AHR also drives the expression of KLF4 and suppresses NF-κB activation in TAMs. Finally, AHR drives the expression of the ectonucleotidase CD39 in TAMs, which promotes CD8

Details

ISSN :
15461726 and 10976256
Volume :
22
Database :
OpenAIRE
Journal :
Nature Neuroscience
Accession number :
edsair.doi.dedup.....9e4859869df4eccdefe630c6ccba688e
Full Text :
https://doi.org/10.1038/s41593-019-0446-8