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Chronic kidney disease in type 2 diabetes: Lessons from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicentre Study
- Source :
- Nutrition, Metabolism and Cardiovascular Diseases. 24:815-822
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- The Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicentre Study is an ongoing observational survey that examines the role of estimated glomerular filtration rate (eGFR) as an independent predictor of cardiovascular and renal outcomes in 15,773 Italian subjects with type 2 diabetes. The analysis of data collected at the enrollment visit provided a picture of chronic kidney disease (CKD) and its association with other complications, risk factors for cardiovascular disease (CVD) and treatments in a large contemporary cohort. Main results of this analysis were that (a) non-albuminuric renal impairment is the predominant clinical phenotype in patients, particularly women, with reduced eGFR; (b) concordance between CKD and diabetic retinopathy is low, with only a minority of patients with renal dysfunction presenting with any or advanced retinal lesions; (c) the non-albuminuric form is associated with a significant prevalence of CVD, especially at the level of the coronary vascular bed; (d) CKD is associated with hemoglobin (Hb) A1c variability more than with average HbA1c, whereas retinopathy and CVD are not; (e) in elderly individuals with moderate-to-severe eGFR reduction, use of agents which are not recommended, such as sulphonylureas and metformin, is still frequent; and (f) though complications are generally more prevalent in men (except non-albuminuric renal impairment) women show a less favorable CVD risk profile and achieve therapeutic targets to a lesser extent than men, despite the fact that treatment intensity is not lower. These data update existing information on the natural history of CKD in patients with type 2 diabetes.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Renal function
Type 2 diabetes
urologic and male genital diseases
End stage renal disease
Coronary artery disease
Sex Factors
Albuminuria
cardiovascular disease
Chronic kidney disease
Diabetic retinopathy
eGFR
Risk Factors
Internal medicine
Prevalence
medicine
Humans
Hypoglycemic Agents
Multicenter Studies as Topic
Renal Insufficiency, Chronic
Intensive care medicine
Glycated Hemoglobin
Nutrition and Dietetics
business.industry
riace
medicine.disease
Metformin
Observational Studies as Topic
Sulfonylurea Compounds
Diabetes Mellitus, Type 2
Italy
Cardiovascular Diseases
Cohort
Female
type 2 diabetes
medicine.symptom
Cardiovascular disease
EGFR
Cardiology and Cardiovascular Medicine
business
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....9e4c4b361ef3402fb3c13863b5683696