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Insights about MYC and Apoptosis in B-Lymphomagenesis: An Update from Murine Models

Authors :
Domenico Augusto Francesco Maisano
Enrico Iaccino
Serena Correnti
Giuseppe Fiume
Ileana Quinto
Selena Mimmi
Eleonora Vecchio
Nancy Nisticò
Salvatore Romano
Source :
International Journal of Molecular Sciences, Vol 21, Iss 4265, p 4265 (2020), International Journal of Molecular Sciences
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

The balance between cell survival and cell death represents an essential part of human tissue homeostasis, while altered apoptosis contributes to several pathologies and can affect the treatment efficacy. Impaired apoptosis is one of the main cancer hallmarks and some types of lymphomas harbor mutations that directly affect key regulators of cell death (such as BCL-2 family members). The development of novel techniques in the field of immunology and new animal models has greatly accelerated our understanding of oncogenic mechanisms in MYC-associated lymphomas. Mouse models are a powerful tool to reveal multiple genes implicated in the genesis of lymphoma and are extensively used to clarify the molecular mechanism of lymphoma, validating the gene function. Key features of MYC-induced apoptosis will be discussed here along with more recent studies on MYC direct and indirect interactors, including their cooperative action in lymphomagenesis. We review our current knowledge about the role of MYC-induced apoptosis in B-cell malignancies, discussing the transcriptional regulation network of MYC and regulatory feedback action of miRs during MYC-driven lymphomagenesis. More importantly, the finding of new modulators of apoptosis now enabling researchers to translate the discoveries that have been made in the laboratory into clinical practice to positively impact human health.

Details

ISSN :
14220067
Volume :
21
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....9e6349ee3294d7c7cc20da885a945355
Full Text :
https://doi.org/10.3390/ijms21124265