Back to Search
Start Over
Insights about MYC and Apoptosis in B-Lymphomagenesis: An Update from Murine Models
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 4265, p 4265 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The balance between cell survival and cell death represents an essential part of human tissue homeostasis, while altered apoptosis contributes to several pathologies and can affect the treatment efficacy. Impaired apoptosis is one of the main cancer hallmarks and some types of lymphomas harbor mutations that directly affect key regulators of cell death (such as BCL-2 family members). The development of novel techniques in the field of immunology and new animal models has greatly accelerated our understanding of oncogenic mechanisms in MYC-associated lymphomas. Mouse models are a powerful tool to reveal multiple genes implicated in the genesis of lymphoma and are extensively used to clarify the molecular mechanism of lymphoma, validating the gene function. Key features of MYC-induced apoptosis will be discussed here along with more recent studies on MYC direct and indirect interactors, including their cooperative action in lymphomagenesis. We review our current knowledge about the role of MYC-induced apoptosis in B-cell malignancies, discussing the transcriptional regulation network of MYC and regulatory feedback action of miRs during MYC-driven lymphomagenesis. More importantly, the finding of new modulators of apoptosis now enabling researchers to translate the discoveries that have been made in the laboratory into clinical practice to positively impact human health.
- Subjects :
- 0301 basic medicine
Programmed cell death
Lymphoma, B-Cell
miRs
B-cells
Review
MYC
Biology
Catalysis
Proto-Oncogene Proteins c-myc
lcsh:Chemistry
Inorganic Chemistry
Mice
03 medical and health sciences
lymphomagenesis
0302 clinical medicine
medicine
Transcriptional regulation
Animals
Humans
Gene Regulatory Networks
mouse models
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Gene
Spectroscopy
Tissue homeostasis
Organic Chemistry
apoptosis
Cancer
General Medicine
medicine.disease
Computer Science Applications
Lymphoma
Gene Expression Regulation, Neoplastic
Disease Models, Animal
MicroRNAs
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Apoptosis
030220 oncology & carcinogenesis
Cancer research
Function (biology)
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....9e6349ee3294d7c7cc20da885a945355
- Full Text :
- https://doi.org/10.3390/ijms21124265