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Temozolomide rechallenge in recurrent glioblastoma: When is it useful?
- Publication Year :
- 2018
-
Abstract
- none 14 no Aim: To identify patients with recurrent glioblastoma after temozolomide (TMZ) concurrent with and adjuvant to radiotherapy who could benefit from TMZ rechallenge at the time of disease progression. Methods: We retrospectively evaluated 106 glioblastoma patients who had nonprogressive disease at first magnetic resonance imaging after completion of TMZ concurrent with and adjuvant to radiotherapy, a treatment-free interval (TFI) of at least 8 weeks and received TMZ rechallenge or a nitrosourea at the time of progression. Results: In patients with TFI ≥5 months, median survival was 17.7 and 11.6 months and median progression-free survival was 8.1 and 5.8 months in the TMZ and nitrosourea group, respectively. Longer TFI was associated with reduced risk for death (p = 0.002) and for disease progression (p = 0.005). Conclusion: TFI ≥5 months represents a predictor of retained TMZ sensitivity. none Franceschi, Enrico; Lamberti, Giuseppe; Visani, Michela; Paccapelo, Alexandro; Mura, Antonella; Tallini, Giovanni; Pession, Annalisa; De Biase, Dario; Minichillo, Santino; Tosoni, Alicia; Di Battista, Monica; Cubeddu, Alessio; Bartolini, Stefania; Brandes, Alba A* Franceschi, Enrico; Lamberti, Giuseppe; Visani, Michela; Paccapelo, Alexandro; Mura, Antonella; Tallini, Giovanni; Pession, Annalisa; De Biase, Dario; Minichillo, Santino; Tosoni, Alicia; Di Battista, Monica; Cubeddu, Alessio; Bartolini, Stefania; Brandes, Alba A*
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Nitrosourea
Cancer Research
nitrosourea
medicine.medical_treatment
rechallenge
O6-methylguanine-DNA methyltransferase
temozolomide
GBM
Disease-Free Survival
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
Humans
In patient
Aged
Temozolomide
medicine.diagnostic_test
business.industry
Brain Neoplasms
Recurrent glioblastoma
glioblastoma
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
MGMT
treatment-free interval
Radiation therapy
Dacarbazine
Treatment Outcome
chemistry
030220 oncology & carcinogenesis
Female
Neoplasm Recurrence, Local
business
Adjuvant
030217 neurology & neurosurgery
medicine.drug
Glioblastoma
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9e6351c6a825d48fad42e99556f8f0f1