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Neonatal seizures and white matter injury: Role of rotavirus infection and probiotics
- Source :
- Braindevelopment. 41(1)
- Publication Year :
- 2017
-
Abstract
- Recent reports associate rotavirus infection with neonatal seizures of distinctive white matter injury (WMI) pattern, but evidence is lacking. We examined this association prospectively and analyzed factors related to occurrence of seizures and WMI pattern in neonates with rotavirus infection.We prospectively included 228 neonates (≥34 gestational weeks) who were admitted to a regional neonatal intensive care unit between February 2015 and April 2016 and underwent rotavirus antigen testing using stool samples. Patients with neonatal seizures of other etiologies were excluded.Seventy-eight (34.2%) neonates were rotavirus-positive. Otherwise-unexplained seizures were more frequently observed among rotavirus-positive than among rotavirus-negative neonates (20.5% vs. 4.0%, p 0.001). Rotavirus infection increased the risk of seizures (odds ratio [OR], 6.19; p 0.001), even after adjustment for confounders (OR, 4.46; p = 0.007). After stratification according to probiotic administration immediately after birth, rotavirus infection remained a significant risk factor only in patients without probiotic medication (OR, 4.83; p = 0.01 vs. OR, 2.44; p = 0.49). The WMI pattern was observed in 9 of 22 neonates with seizures, and this subgroup was characterized by rotavirus infection (100% vs. 53.8%, p = 0.004) and seizure onset on days 4-6 of life (66.7% vs. 15.0%; p = 0.02). G9P[8] was the most common genotype in this subgroup but was also commonly detected in neonates without seizures.Rotavirus infection is an independent risk factor for neonatal seizures, and associated with the WMI. Immediate administration of probiotics after birth may reduce rotavirus-associated neonatal seizures.
- Subjects :
- Male
Rotavirus
Pediatrics
medicine.medical_specialty
Rotavirus Antigen
Neonatal intensive care unit
viruses
medicine.disease_cause
Rotavirus Infections
03 medical and health sciences
fluids and secretions
0302 clinical medicine
Developmental Neuroscience
Risk Factors
Seizures
Gestational Weeks
Medicine
Humans
Prospective Studies
Risk factor
business.industry
Probiotics
White Matter Injury
Infant, Newborn
virus diseases
General Medicine
Magnetic Resonance Imaging
White Matter
Rotavirus infection
Pediatrics, Perinatology and Child Health
Etiology
Intensive Care, Neonatal
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18727131
- Volume :
- 41
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Braindevelopment
- Accession number :
- edsair.doi.dedup.....9eb9058b715e00aa1e3428fc76416ceb