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Characterization of Adnexal Masses Using Contrast‐Enhanced Subharmonic Imaging: A Pilot Study
- Source :
- J Ultrasound Med
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- OBJECTIVES—: This pilot study evaluated whether contrast-enhanced subharmonic imaging (SHI) could be used to characterize adnexal masses before surgical intervention. METHODS—: Ten women (with 12 lesions) scheduled for surgery of an ovarian mass underwent an SHI examination of their adnexal region using a modified LOGIQ E9 scanner (GE Healthcare, Waukesha, WI) with an endocavitary transducer, in which digital clips were acquired by pulse destruction-replenishment SHI across the lesions. Time-intensity curves were created offline to quantitatively evaluate SHI parameters (fractional tumor perfusion, peak contrast intensity, time to peak contrast enhancement, and area under the time-intensity curve), which were compared to pathologic characterizations of the lesions. RESULTS—: Of the 12 masses, 8 were benign, and 4 were malignant. A qualitative analysis of the SHI images by an experienced radiologist resulted in diagnostic accuracy of 70%, compared to 56% without contrast, whereas an inexperienced radiologist improved from 50% to 58% accuracy, demonstrating the benefit of SHI. A quantitative analysis of SHI parameters produced diagnostic accuracy as high as 81%. Peak contrast intensity was significantly greater in malignant than benign masses (mean ± SD, 0.109 ± 0.088 versus 0.046 ± 0.030 arbitrary units; P = .046). Malignant masses also showed significantly greater perfusion than benign masses (24.79% ± 25.34% versus 7.62% ± 6.50%; P = .045). When the radiologist reads were combined with the most predictive quantitative SHI parameter (percent perfusion), diagnostic accuracy improved to 84% for the experienced radiologist and 96% for the novice radiologist. CONCLUSIONS—: Results indicate that SHI for presurgical characterization of adnexal masses may improve the determination of malignancy and diagnostic accuracy, albeit based on a small sample size.
- Subjects :
- Adult
media_common.quotation_subject
Arbitrary unit
Contrast Media
Pilot Projects
Malignancy
Article
030218 nuclear medicine & medical imaging
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Adnexa Uteri
Tumor perfusion
medicine
Humans
Contrast (vision)
Radiology, Nuclear Medicine and imaging
Aged
Ultrasonography
media_common
Ovarian Neoplasms
Subharmonic
030219 obstetrics & reproductive medicine
Radiological and Ultrasound Technology
business.industry
fungi
Reproducibility of Results
Small sample
Middle Aged
Image Enhancement
medicine.disease
Intensity (physics)
Adnexal Diseases
Female
Nuclear medicine
business
Perfusion
Subjects
Details
- ISSN :
- 15509613 and 02784297
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Journal of Ultrasound in Medicine
- Accession number :
- edsair.doi.dedup.....9ec623773896662674f1dd7d5239eac1