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Evaluation of somatic genomic imbalances in thyroid carcinomas of follicular origin by CGH-based approaches
- Source :
- Minerva endocrinologica. 43(3)
- Publication Year :
- 2017
-
Abstract
- Application of distinct technologies of cancer genome analysis has provided important information for the molecular characterization of several human neoplasia, including follicular cell-derived thyroid carcinoma. Among them, comparative genomic hybridization (CGH)-based procedures have been extensively applied to evaluate genomic imbalances present in these tumours, obtaining data leading to an increase in the understanding of their complexity and diversity. In this review, after a brief overview of the most commonly used CGH-based technichs, we will describe the major results deriving from the most influential studies in the literature which used this approach to investigate the genomic aberrations of thyroid cancer cells. In most studies a small number of patients have been analyzed. Deletions and duplications at different chromosomal regions were detected in all investigated cohorts. A higher number of genomic imbalances has been detected in anaplastic or poorly differentiated thyroid carcinomas compared to well differentiated ones. Limitations in the interpretation of the results, as well the potential impact in the clinical practice are discussed. Though a quite heterogeneous picture arises from results so far available, CGH array, combined with other methodologies as well as an accurate clinical management, may offer novel opportunities for a better stratification of thyroid cancer patients.
- Subjects :
- 0301 basic medicine
Comparative genomic hybridization
Mutation
Thyroid neoplasms
Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology
Somatic cell
Genomics
Computational biology
medicine.disease_cause
Thyroid carcinoma
03 medical and health sciences
0302 clinical medicine
Follicular phase
Adenocarcinoma, Follicular
Medicine
Humans
Thyroid Neoplasms
Thyroid cancer
Comparative Genomic Hybridization
business.industry
medicine.disease
Diabetes and Metabolism
030104 developmental biology
030220 oncology & carcinogenesis
Adenocarcinoma
business
Subjects
Details
- ISSN :
- 18271634
- Volume :
- 43
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Minerva endocrinologica
- Accession number :
- edsair.doi.dedup.....9ec91bd9cd375d67f5ac0513dc63be94