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Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics
- Source :
- Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018), Acta Neuropathologica Communications, den Haan, J, Morrema, T H J, Rozemuller, A J, Bouwman, F H & Hoozemans, J J M 2018, ' Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer's disease brains : Implications for in-vivo diagnostics ', Acta Neuropathologica Communinications, vol. 6, no. 1, pp. 75 . https://doi.org/10.1186/s40478-018-0577-2, Acta Neuropathologica Communinications, 6(1). BioMed Central
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- The combined fluorescent and Aβ-binding properties of the dietary spice curcumin could yield diagnostic purpose in the search for a non-invasive Aβ-biomarker for Alzheimer’s disease (AD). However, evidence on the binding properties of curcumin, its conjugates and clinically used bio-available formulations to AD neuropathological hallmarks is scarce. We therefore assessed the binding properties of different curcumin forms to different neuropathological deposits in post-mortem brain tissue of cases with AD, other neurodegenerative diseases, and controls. Post mortem brain tissue was histochemically assessed for the binding of curcumin, its isoforms, conjugates and bio-available forms and compared to routinely used staining methods. For this study we included brains of early onset AD, late onset AD, primary age-related tauopathy (PART), cerebral amyloid angiopathy (CAA), frontotemporal lobar degeneration (FTLD) with tau or TAR DNA-binding protein 43 (TDP-43) inclusions, dementia with Lewy bodies (DLB), Parkinson’s disease (PD) and control cases without brain pathology. We found that curcumin binds to fibrillar amyloid beta (Aβ) in plaques and CAA. It does not specifically bind to inclusions of protein aggregates in FTLD-tau cases, TDP-43, or Lewy bodies. Curcumin isoforms, conjugates and bio-available forms show affinity for the same Aβ structures. Curcumin staining overlaps with immunohistochemical detection of Aβ in fibrillar plaques and CAA, and to a lesser extent cored plaques. A weak staining of neurofibrillary tangles was observed, while other structures immunopositive for phosphorylated tau remained negative. In conclusion, curcumin, its isoforms, conjugates and bio-available forms selectively bind fibrillar Aβ in plaques and CAA in post mortem AD brain tissue. Curcumin, being a food additive with fluorescent properties, is therefore an interesting candidate for in-vivo diagnostics in AD, for example in retinal fluorescent imaging.
- Subjects :
- 0301 basic medicine
Male
Pathology
Plaque, Amyloid
Protein aggregation
lcsh:RC346-429
chemistry.chemical_compound
0302 clinical medicine
Aged, 80 and over
biology
Neurodegeneration
Anti-Inflammatory Agents, Non-Steroidal
Brain
Neurofibrillary Tangles
Frontotemporal lobar degeneration
Middle Aged
Immunohistochemistry
DNA-Binding Proteins
Tauopathies
Female
Cerebral amyloid angiopathy
Tauopathy
Autopsy
Amyloid-beta
Alzheimer’s disease
Protein Binding
medicine.medical_specialty
Curcumin
Amyloid beta
tau Proteins
Cerebral amyloid angiopathy (CAA)
Pathology and Forensic Medicine
03 medical and health sciences
Cellular and Molecular Neuroscience
Alzheimer Disease
mental disorders
medicine
Humans
lcsh:Neurology. Diseases of the nervous system
Aged
Retrospective Studies
Amyloid beta-Peptides
Dementia with Lewy bodies
Research
Biomarker
medicine.disease
Cerebral Amyloid Angiopathy
030104 developmental biology
chemistry
biology.protein
Neurology (clinical)
Frontotemporal Lobar Degeneration
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20515960
- Volume :
- 6
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Acta Neuropathologica Communications
- Accession number :
- edsair.doi.dedup.....9ed4d6594a8ef93e3e5b1571bb54b40f
- Full Text :
- https://doi.org/10.1186/s40478-018-0577-2