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Resistance to apoptosis should not be taken as a hallmark of cancer
- Source :
- Chinese Journal of Cancer
- Publication Year :
- 2014
- Publisher :
- Editorial Office of Chinese Journal of Cancer, 2014.
-
Abstract
- In the research community, resistance to apoptosis is often considered a hallmark of cancer. However, pathologists who diagnose cancer via microscope often see the opposite. Indeed, increased apoptosis and mitosis are usually observed simultaneously in cancerous lesions. Studies have shown that increased apoptosis is associated with cancer aggressiveness and poor clinical outcome. Furthermore, overexpression of Bcl-2, an antiapoptotic protein, is linked with better survival of cancer patients. Conversely, Bax, CD95, Caspase-3, and other apoptosis-inducing proteins have been found to promote carcinogenesis. This notion of the role of apoptosis in cancer is not new; cancer cells were found to be short-lived 88 years ago. Given these observations, resistance to apoptosis should not be considered a hallmark of cancer.
- Subjects :
- Lymphoma, B-Cell
Carcinogenesis
Controversy
Caspase 3
medicine.disease_cause
Bcl-2-associated X protein
Neoplasms
hallmark
Biomarkers, Tumor
medicine
Animals
Humans
Bcl-2
fas Receptor
Mitosis
Cancer
bcl-2-Associated X Protein
biology
business.industry
apoptosis
medicine.disease
Fas receptor
Treatment Outcome
Proto-Oncogene Proteins c-bcl-2
Oncology
Apoptosis
Immunology
Cancer cell
Cancer research
biology.protein
business
Subjects
Details
- ISSN :
- 1944446X and 1000467X
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Cancer
- Accession number :
- edsair.doi.dedup.....9ee22af1f76d469e856e96499c6dc8da